Results 131 to 140 of about 1,077,335 (347)

Exploring molecular mechanisms of drug resistance in bacteria and progressions in CRISPR/Cas9-based genome expurgation solutions

Global Medical Genetics
Antibiotic resistance in bacteria is a critical global health challenge, driven by molecular mechanisms such as genetic mutations, efflux pumps, enzymatic degradation of antibiotics, target site modifications, and biofilm formation.
K.E. Vivekanandan, P. Vinoth Kumar, R.C. Jaysree, T. Rajeshwari   +3 more
doaj   +1 more source

Investigating colistin drug resistance: The role of high-throughput sequencing and bioinformatics [version 2; peer review: 2 approved]

F1000Research, 2019
Bacterial infections involving antibiotic-resistant gram-negative bacteria continue to increase and represent a major global public health concern.
Dickson Aruhomukama, Ivan Sserwadda, Gerald Mboowa   +2 more
doaj   +1 more source

Inhibiting Bacterial Drug Efflux Pumps via Phyto-Therapeutics to Combat Threatening Antimicrobial Resistance

Frontiers in Microbiology, 2018
Antibiotics, once considered the lifeline for treating bacterial infections, are under threat due to the emergence of threatening antimicrobial resistance (AMR). These drug-resistant microbes (or superbugs) are non-responsive to most of the commonly used
V. Shriram, T. Khare, R. Bhagwat, R. Shukla, Vinay Kumar   +4 more
semanticscholar   +1 more source

Drug-Resistant Bacterial Infections and Alternative Therapies

Biomedicines
The introduction of antibiotics in clinical use has revolutionized modern medicine practices and significantly contributed to the control of bacterial infections, which were the leading cause of morbidity and mortality throughout human history [...]
openaire   +3 more sources

Amide‐Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non‐Small Cell Lung Adenocarcinoma

Advanced Biology, EarlyView.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta‐Carolin Pietsch, Sebastian N. Stehr, Sonja Kallendrusch, Tobias Piegeler   +8 more
wiley   +1 more source

Ontological representation of CDC Active Bacterial Core Surveillance Case Reports [PDF]

, 2014
The Center for Disease Control and Prevention’s Active Bacterial Core Surveillance (CDC ABCs) Program is a collaborative effort betweeen the CDC, state health departments, laboratories, and universities to track invasive bacterial pathogens of particular
Cowell, Lindsay G., Goldfain, Albert, Smith, Barry   +2 more
core  

Editorial: Gram-Negative Pathogenesis

Frontiers in Microbiology, 2021
Hidetada Hirakawa, Christophe Bordi, Haruyoshi Tomita, Haruyoshi Tomita   +3 more
doaj   +1 more source

Complementary supramolecular drug associates in perfecting the multidrug therapy against multidrug resistant bacteria

Frontiers in Immunology
The inappropriate and inconsistent use of antibiotics in combating multidrug-resistant bacteria exacerbates their drug resistance through a few distinct pathways.
Pathik Sahoo, Pathik Sahoo
doaj   +1 more source

Multiple drug resistance bacterial isolates and associated factors among urinary stone patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. [PDF]

BMC Urol, 2021
Kasew D, Eshetie S, Diress A, Tegegne Z, Moges F.   +4 more
europepmc   +1 more source

Deciphering the Origin of Higher Shell Coordination on Single Iron Catalysts for Resilient Modulating Persulfate Oxidation Into Singlet Oxygen Pathway

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
This study reveals that higher shell S coordination can effectively modulate the spin state of FeN4 site via long‐range electronic interactions, giving rise to the oriented generation of singlet oxygen from peroxymonosulfate activation. Abstract Precise manipulation of coordination structure of single‐atom sites and establishment of schematic ...
Liang Zhang, Kai Cheng, Zhizhi Yang, Ye Zhang, Shiro Kubuki, Paul A. Bingham, Yang‐Chun Yong, Bofan Zhang, Xiaoguang Duan   +8 more
wiley   +1 more source