Results 181 to 190 of about 2,311,261 (354)

Pattern of primary tuberculosis drug resistance and associated risk factors at Dubai health authority in Dubai

, 2020
Maya Habous, Maimona Elimam, Laila AlDabal, Bindu Chidambaran, Zulfa O. AlDeesi   +4 more
openalex   +1 more source

mTORC2 dictates Warburg effect and drug resistance [PDF]

, 2014
Kenta Masui, Webster K. Cavenee, Paul S. Mischel   +2 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Medicinal Plants for Overcoming Drug Resistance in Cervical Cancer. [PDF]

Biology (Basel)
Marema TP, Laka K, Mbita Z.
europepmc   +1 more source

Plasmodium falciparum drug resistance gene status in the Horn of Africa: A systematic review [PDF]

, 2018
Abdullahi Jalei Abdifatah, Chaijaroenkul Wanna, Na-Bangchang Kesara   +2 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

DRESIS 2.0: the comprehensive landscape of drug resistance information. [PDF]

Nucleic Acids Res
Sun X, Wei Z, Yu X, Liu K, Yao S, Ni Z, Wang H, Zhao Z, Zhang Y, Liu Y, Ding H, Zhang Y, Liu Z, Xiao M, Zhu F.   +14 more
europepmc   +1 more source

Integrated Genomic Profiling Reveals Mechanisms of Broad Drug Resistance and Opportunities for Phenotypic Reprogramming in Cancer Cells [PDF]

Ian Mersich, Brian S. J. Blagg, Aktar Ali   +2 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source