Results 191 to 200 of about 8,220,454 (420)
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source
Combination versus sequential monotherapy in chronic HBV infection: a mathematical approach [PDF]
arXiv, 2013 Sequential monotherapy is the most widely used therapeutic approach in the treatment of HBV chronic infection. Unfortunately, under therapy, in some patients the hepatitis virus mutates and gives rise to variants which are drug resistant. We conjecture that combination therapy is able to delay drug resistance for a longer time than sequential ...
arxiv
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source
The Role of Antibodies in Experimental Drug Resistance of Trypanosoma Equiperdum [PDF]
, 1946 R. Schnitzer +2 more
openalex +1 more source
Drug resistance and tolerance in fungi
Nature Reviews Microbiology, 2020 J. Berman, D. Krysan
semanticscholar +1 more source
Knowledge and Attitude of Students on Antimicrobial Resistance at Debre Markos University, Ethiopia [PDF]
, 2016 Irrational use of medicines is a key reason for the increase and spread of antimicrobial resistance and it is a global concern. It is a fast mounting universal crisis. The main of this study of this study was to assess knowledge, attitude and practice of
Bizuayehu, H. M. (Habtamu) +1 more
core
Molecular Oncology, EarlyView.Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source