Results 201 to 210 of about 2,311,261 (354)

Epigenetic basis of cancer drug resistance

, 2020
Moammir Hasan Aziz, Aamir Ahmad
openalex   +2 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Clinical application and drug resistance mechanism of gemcitabine. [PDF]

Front Cell Dev Biol
Zhang X, Qi B, Chen J.
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Model-guided geospatial surveillance system for antimalarial drug resistance. [PDF]

PLOS Glob Public Health
Gupta A, Harrison LE, Nain M, Phulgenda SS, Chhajed R, Kumar RS, Das A, Rahi M, Guerin PJ, Anvikar AR, Dhorda M, Flegg JA, Bharti PK.   +12 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Regulation of RNA methylation linked to drug resistance in gastric cancer. [PDF]

Front Cell Dev Biol
Yang Z, Ma Y, Xu Z, Liu H, Gu X, Sun J.
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Exosomes in cancer metabolism and drug resistance: A review. [PDF]

Biomol Biomed
Mohammed O, Ahmed Assaye M, Alemayehu E, Tufa A, Genet S.   +4 more
europepmc   +1 more source

Antituberculosis Drugs Resistance and Treatment Outcomes Among Retreatment Patients in Guinea: A Five-Year Retrospective Cohort Study [PDF]

, 2019
Tamba Kallas Tonguino, Tamba Mina Millimouno, Boubacar Diallo, Alexandre Délamou, Nimer Ortuño‐Gutiérrez, Mory Camara, Boubacar Bah, Oumou Younoussa Sow   +7 more
openalex   +1 more source