Results 221 to 230 of about 2,311,261 (354)

The lncrnas: innovative multifunctional players of drug resistance in colorectal cancer. [PDF]

Cancer Cell Int
Maghsoudi H, Rasoulzadeh M, Abbastabar M, Fazilat A, Sheikhnia F, Azizzadeh B, Valilo M, Majidinia M.   +7 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Next-Generation Sequencing and Bioinformatics Protocol for Malaria Drug Resistance Marker Surveillance [PDF]

, 2018
Eldin Talundzic, Shashidhar Ravishankar, Julia Kelley, Dhruviben Patel, Mateusz M. Pluciński, Sarah E. Schmedes, Dragan Ljolje, Brooke Clemons, Susan Madison‐Antenucci, Paul M. Arguin, Naomi W. Lucchi, Fredrik Vannberg, Venkatachalam Udhayakumar   +12 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Targeting of SKP2 to combat drug resistance in multiple myeloma. [PDF]

Sci Rep
Faruq O, Ngo J, Iyer D, Nesson J, Shrestha M, Chang H.   +5 more
europepmc   +1 more source

Surveys of Transmitted HIV Drug Resistance in 7 Geographic Regions in China, 2008–2009 [PDF]

, 2012
Lingjie Liao, Hui Xing, Yonghui Dong, Guangming Qin, Yanling Ma, Hongyan Lu, Lin Chen, Lan Zhang, Connie Osborne, Nicole Seguy, Daying Wei, Feng Sun, Juan Yang, Yuhua Ruan, Yiming Shao   +14 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Surveillance and analysis of drug resistance and drug resistance levels in multidrug resistant tuberculosis on the tropical islands of China. [PDF]

BMC Infect Dis
Wang J, Dong J, Chen Z, Xu Y, Qiu W, Chen S, Pei H, Zhong Y.   +7 more
europepmc   +1 more source

Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer [PDF]

, 2018
Teresa Kaserer, Julian Blagg
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source