Results 311 to 320 of about 2,275,826 (357)
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Glutathione and Drug Resistance
Cancer Investigation, 1996(1996). Glutathione and Drug Resistance. Cancer Investigation: Vol. 14, No. 2, pp. 158-168.
C P, Schröder +5 more
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Resistance to the nitroheterocyclic drugs
Acta Tropica, 1994The nitroheterocyclic drugs have been available since the early 1960's for the treatment of anaerobic protozoa. The application of these drugs has widened since then and they are presently used to treat anaerobic pathogenic bacteria and protozoa. The activity of the nitroheterocyclic drugs depends on the all-important nitro group attached to the ...
S M, Townson +3 more
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Annual Review of Pharmacology and Toxicology, 1992
Infection with human immunodeficiency virus (HIV) is a chronic process with persistent, high rates of replication. The virus exhibits high rates of mutation over time within the same individual. It is thus not surprising that drug-resis tant mutants of HIV emerge under the selective pressure of prolonged chemotherapy, especially with the knowledge of ...
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Infection with human immunodeficiency virus (HIV) is a chronic process with persistent, high rates of replication. The virus exhibits high rates of mutation over time within the same individual. It is thus not surprising that drug-resis tant mutants of HIV emerge under the selective pressure of prolonged chemotherapy, especially with the knowledge of ...
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New England Journal of Medicine, 1996
Since their discovery, antimicrobial drugs have proved remarkably effective for the control of bacterial infections. However, it was soon evident that bacterial pathogens were unlikely to surrender unconditionally, because some pathogens rapidly became resistant to many of the first effective drugs.
H S, Gold, R C, Moellering
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Since their discovery, antimicrobial drugs have proved remarkably effective for the control of bacterial infections. However, it was soon evident that bacterial pathogens were unlikely to surrender unconditionally, because some pathogens rapidly became resistant to many of the first effective drugs.
H S, Gold, R C, Moellering
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[Antimalarial drug resistance].
Medecine et maladies infectieuses, 2006Drug resistant malaria is mostly due to Plasmodium falciparum, the highly prevalent species in tropical Africa, Amazon, and Southeast Asia. P. falciparum is responsible for severe involvement of fever or anemia causing more than a million deaths per year.
Le Bras, J., Musset, L., Clain, J.
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New England Journal of Medicine, 2011
Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines how this diagnosis should be established and how to recognize pseudoresistance. It explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.
Patrick, Kwan +2 more
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Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines how this diagnosis should be established and how to recognize pseudoresistance. It explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.
Patrick, Kwan +2 more
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Resistance to Castration – Resistance to Drugs
2013Up to 70 % of newly diagnosed patients with advanced prostate cancer (PCa) will progress to castration-resistant prostate cancer (CRPC) and, in most cases (from 50 to 70 %), will develop hematogenous bone metastasis. Once PCa cells spread to the skeleton, cancer-related death becomes inevitable, with a death burden of more than 28,000 cases in 2012, in
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DRUG RESISTANCE IN TUBERCULOSIS
Infectious Disease Clinics of North America, 1997Drug-resistant tuberculosis remains a worldwide problem. New laboratory methods have improved our ability to more rapidly identify resistant strains, but the most effective approach is to prevent the appearance of resistance by appropriate choice of antibiotics and directly-observed therapy.
L M, Parsons +3 more
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2010
This chapter provides an overview of our current understanding of the mechanisms associated with the development of antimicrobial drug resistance, international differences in definitions of resistance, ongoing efforts to track shifts in drug susceptibility, and factors that can influence the selection of therapeutic intervention. The latter presents a
Marilyn, Martinez, Peter, Silley
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This chapter provides an overview of our current understanding of the mechanisms associated with the development of antimicrobial drug resistance, international differences in definitions of resistance, ongoing efforts to track shifts in drug susceptibility, and factors that can influence the selection of therapeutic intervention. The latter presents a
Marilyn, Martinez, Peter, Silley
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Trends in Microbiology, 1994
The mechanisms of action of antiviral drugs and of drug resistance are known in remarkable detail, partly because X-ray crystallographic structures are known for many target viral proteins. Resistance usually involves amino acid substitutions in the target protein that prevent drug binding or prevent an enzyme from accepting the drug as a substrate ...
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The mechanisms of action of antiviral drugs and of drug resistance are known in remarkable detail, partly because X-ray crystallographic structures are known for many target viral proteins. Resistance usually involves amino acid substitutions in the target protein that prevent drug binding or prevent an enzyme from accepting the drug as a substrate ...
openaire +2 more sources