Results 311 to 320 of about 8,379,718 (351)
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Mechanisms of drug resistance in HCC
Hepatology, 2023HCC comprises ∼80% of primary liver cancer. HCC is the only major cancer for which death rates have not improved over the last 10 years. Most patients are diagnosed with advanced disease when surgical and locoregional treatments are not feasible or ...
Alexandra D. Ladd +3 more
semanticscholar +1 more source
Drug Discovery Today: Technologies, 2014
Drug resistance is a fundamental problem in the treatment of cancer since cancer that becomes resistant to the available drugs may leave the patient with no therapeutic alternatives. In this chapter, we consider the dynamics of drug resistance in blood cancer and the related issue of the dynamics of cancer stem cells. After describing the main types of
Gemma, Texidó, Jürgen, Moll
+6 more sources
Drug resistance is a fundamental problem in the treatment of cancer since cancer that becomes resistant to the available drugs may leave the patient with no therapeutic alternatives. In this chapter, we consider the dynamics of drug resistance in blood cancer and the related issue of the dynamics of cancer stem cells. After describing the main types of
Gemma, Texidó, Jürgen, Moll
+6 more sources
Drug resistance in schistosomes
Parasitology Today, 1993Drug resistance in schistosomes is confined essentially to compounds of the hyconthone/oxamniquine family, since no documented case of resistance has so far been reported for the widely used drug praziquantel. The availability of strains of Schistosoma mansoni that are resistant to hyconthone and oxomniquine has permitted a detailed genetic and ...
Cioli D, PicaMattoccia L, Valle C
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British Medical Bulletin, 1991
Chemotherapy cures a minority of adult tumours (e.g. Hodgkin's and non-Hodgkin's lymphoma, acute leukaemia, teratoma) and the majority of childhood tumours. Prolongation of survival by chemotherapy has been shown for small cell lung cancer, ovarian cancer and breast carcinoma (when used as an adjuvant).
D, Hochhauser, A L, Harris
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Chemotherapy cures a minority of adult tumours (e.g. Hodgkin's and non-Hodgkin's lymphoma, acute leukaemia, teratoma) and the majority of childhood tumours. Prolongation of survival by chemotherapy has been shown for small cell lung cancer, ovarian cancer and breast carcinoma (when used as an adjuvant).
D, Hochhauser, A L, Harris
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New England Journal of Medicine, 2011
Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines how this diagnosis should be established and how to recognize pseudoresistance. It explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.
Yoko Ohtsuka +2 more
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Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines how this diagnosis should be established and how to recognize pseudoresistance. It explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.
Yoko Ohtsuka +2 more
openaire +8 more sources
2012
Abstract Despite the ongoing development of novel AEDs, drug resistance remains a major problem in the clinical management of epilepsy patients. Thus, strategies to break new grounds in the development of novel AEDs or alternative therapeutic approaches are urgently needed.
Gorter, J.A., Potschka, H.
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Abstract Despite the ongoing development of novel AEDs, drug resistance remains a major problem in the clinical management of epilepsy patients. Thus, strategies to break new grounds in the development of novel AEDs or alternative therapeutic approaches are urgently needed.
Gorter, J.A., Potschka, H.
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Annual Review of Pharmacology and Toxicology, 1992
Infection with human immunodeficiency virus (HIV) is a chronic process with persistent, high rates of replication. The virus exhibits high rates of mutation over time within the same individual. It is thus not surprising that drug-resis tant mutants of HIV emerge under the selective pressure of prolonged chemotherapy, especially with the knowledge of ...
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Infection with human immunodeficiency virus (HIV) is a chronic process with persistent, high rates of replication. The virus exhibits high rates of mutation over time within the same individual. It is thus not surprising that drug-resis tant mutants of HIV emerge under the selective pressure of prolonged chemotherapy, especially with the knowledge of ...
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Challenges and Opportunities in Cancer Drug Resistance.
Chemical Reviews, 2020There has been huge progress in the discovery of targeted cancer therapies in recent years. However, even for the most successful and impactful cancer drugs which have been approved, both innate and acquired mechanisms of resistance are commonplace ...
R. Ward +5 more
semanticscholar +1 more source
Multi-Drug Resistant and Extensively-Drug Resistant Tuberculosis
The Indian Journal of Pediatrics, 2020India is one of the high burden countries for tuberculosis (TB) including multi-drug resistant TB (MDR-TB) and extensively-drug resistant (XDR) TB. Drug-resistant (DR) TB has threatened the TB care and is a major health problem in many countries; treatment of DR TB has been difficult requiring use of reserve or second-line drugs, cost factors, has ...
Ira Shah +2 more
openaire +3 more sources
Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
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