Results 311 to 320 of about 2,311,261 (354)
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New England Journal of Medicine, 1996
Since their discovery, antimicrobial drugs have proved remarkably effective for the control of bacterial infections. However, it was soon evident that bacterial pathogens were unlikely to surrender unconditionally, because some pathogens rapidly became resistant to many of the first effective drugs.
H S, Gold, R C, Moellering
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Since their discovery, antimicrobial drugs have proved remarkably effective for the control of bacterial infections. However, it was soon evident that bacterial pathogens were unlikely to surrender unconditionally, because some pathogens rapidly became resistant to many of the first effective drugs.
H S, Gold, R C, Moellering
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2010
This chapter provides an overview of our current understanding of the mechanisms associated with the development of antimicrobial drug resistance, international differences in definitions of resistance, ongoing efforts to track shifts in drug susceptibility, and factors that can influence the selection of therapeutic intervention. The latter presents a
Marilyn, Martinez, Peter, Silley
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This chapter provides an overview of our current understanding of the mechanisms associated with the development of antimicrobial drug resistance, international differences in definitions of resistance, ongoing efforts to track shifts in drug susceptibility, and factors that can influence the selection of therapeutic intervention. The latter presents a
Marilyn, Martinez, Peter, Silley
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Annual Review of Pharmacology and Toxicology, 1992
Infection with human immunodeficiency virus (HIV) is a chronic process with persistent, high rates of replication. The virus exhibits high rates of mutation over time within the same individual. It is thus not surprising that drug-resis tant mutants of HIV emerge under the selective pressure of prolonged chemotherapy, especially with the knowledge of ...
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Infection with human immunodeficiency virus (HIV) is a chronic process with persistent, high rates of replication. The virus exhibits high rates of mutation over time within the same individual. It is thus not surprising that drug-resis tant mutants of HIV emerge under the selective pressure of prolonged chemotherapy, especially with the knowledge of ...
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Trends in Pharmacological Sciences, 1989
Recently the first report of zidovudine-resistant human immunodeficiency virus obtained from AIDS patients was published. Resistance to antiviral agents may result from single point mutations in the virus genome. Several mechanisms of resistance have already been elucidated at the biochemical level but the clinical significance of drug resistance is ...
H J, Field, S E, Goldthorpe
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Recently the first report of zidovudine-resistant human immunodeficiency virus obtained from AIDS patients was published. Resistance to antiviral agents may result from single point mutations in the virus genome. Several mechanisms of resistance have already been elucidated at the biochemical level but the clinical significance of drug resistance is ...
H J, Field, S E, Goldthorpe
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Endeavour, 1984
Abstract Since it was introduced into Europe from South America by the Jesuits at the beginning of the 17th century, quinine has been one of the most effective drugs for the treatment of malaria. During this century a number of synthetic antimalarial drugs have been introduced but while these have had considerable success their extensive and ...
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Abstract Since it was introduced into Europe from South America by the Jesuits at the beginning of the 17th century, quinine has been one of the most effective drugs for the treatment of malaria. During this century a number of synthetic antimalarial drugs have been introduced but while these have had considerable success their extensive and ...
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Antiviral Research, 2006
Almost 30 years ago it was proposed that the selection for antiviral drug resistance should be used as an indicator of antiviral drug activity. In addition to discriminating between cellular toxicity and specific activity directed against a viral target, drug resistant mutants have been used to confirm the mechanism of action of antiviral drugs, to ...
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Almost 30 years ago it was proposed that the selection for antiviral drug resistance should be used as an indicator of antiviral drug activity. In addition to discriminating between cellular toxicity and specific activity directed against a viral target, drug resistant mutants have been used to confirm the mechanism of action of antiviral drugs, to ...
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Clinical Infectious Diseases, 2003
The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term ...
Juergen, Loeffler, David A, Stevens
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The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term ...
Juergen, Loeffler, David A, Stevens
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1955
Publisher Summary It is unfeasible and unnecessary to coerce the complex biological events contributing to the origin of resistance into a single theory. Experimental evidence suggests that a few models define most examples of resistance development, particularly if the models are so combined as to provide either genotypic or phenotypic alterations ...
V, BRYSON, W, SZYBALSKI
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Publisher Summary It is unfeasible and unnecessary to coerce the complex biological events contributing to the origin of resistance into a single theory. Experimental evidence suggests that a few models define most examples of resistance development, particularly if the models are so combined as to provide either genotypic or phenotypic alterations ...
V, BRYSON, W, SZYBALSKI
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Seminars in Respiratory and Critical Care Medicine, 2011
Influenza viruses are major human pathogens with a global distribution, accounting for more than 500,000 annual deaths worldwide and with considerable impact on the quality of life and productivity of the society. Due to the limited efficacy of vaccination, antiviral drugs constitute a complementary approach in the control and prevention of influenza ...
Andrés, Pizzorno +2 more
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Influenza viruses are major human pathogens with a global distribution, accounting for more than 500,000 annual deaths worldwide and with considerable impact on the quality of life and productivity of the society. Due to the limited efficacy of vaccination, antiviral drugs constitute a complementary approach in the control and prevention of influenza ...
Andrés, Pizzorno +2 more
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Disease-a-Month, 2006
Eastern Europe, Henan province in China, and certain parts of Russia. 1 The resistance to single drug was reported to range from 2 to 41% (median 9.9%) and to multiple drugs was 0 to 14.4% (prevalence 1.4%) in those who never received prior treatment.
Joel Anthony, Nations +2 more
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Eastern Europe, Henan province in China, and certain parts of Russia. 1 The resistance to single drug was reported to range from 2 to 41% (median 9.9%) and to multiple drugs was 0 to 14.4% (prevalence 1.4%) in those who never received prior treatment.
Joel Anthony, Nations +2 more
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