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DRUG RESISTANCE IN TUBERCULOSIS
Infectious Disease Clinics of North America, 1997Drug-resistant tuberculosis remains a worldwide problem. New laboratory methods have improved our ability to more rapidly identify resistant strains, but the most effective approach is to prevent the appearance of resistance by appropriate choice of antibiotics and directly-observed therapy.
Max Salfinger +3 more
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Critical reviews in biochemistry and molecular biology, 1995
The glutathione S-transferases (GST) represent a major group of detoxification enzymes. All eukaryotic species possess multiple cytosolic and membrane-bound GST isoenzymes, each of which displays distinct catalytic as well as noncatalytic binding ...
J. Hayes, D. Pulford
semanticscholar +1 more source
The glutathione S-transferases (GST) represent a major group of detoxification enzymes. All eukaryotic species possess multiple cytosolic and membrane-bound GST isoenzymes, each of which displays distinct catalytic as well as noncatalytic binding ...
J. Hayes, D. Pulford
semanticscholar +1 more source
2010
This chapter provides an overview of our current understanding of the mechanisms associated with the development of antimicrobial drug resistance, international differences in definitions of resistance, ongoing efforts to track shifts in drug susceptibility, and factors that can influence the selection of therapeutic intervention. The latter presents a
Peter Silley, Marilyn N. Martinez
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This chapter provides an overview of our current understanding of the mechanisms associated with the development of antimicrobial drug resistance, international differences in definitions of resistance, ongoing efforts to track shifts in drug susceptibility, and factors that can influence the selection of therapeutic intervention. The latter presents a
Peter Silley, Marilyn N. Martinez
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Trends in Microbiology, 1994
The mechanisms of action of antiviral drugs and of drug resistance are known in remarkable detail, partly because X-ray crystallographic structures are known for many target viral proteins. Resistance usually involves amino acid substitutions in the target protein that prevent drug binding or prevent an enzyme from accepting the drug as a substrate ...
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The mechanisms of action of antiviral drugs and of drug resistance are known in remarkable detail, partly because X-ray crystallographic structures are known for many target viral proteins. Resistance usually involves amino acid substitutions in the target protein that prevent drug binding or prevent an enzyme from accepting the drug as a substrate ...
openaire +3 more sources
Endeavour, 1984
Abstract Since it was introduced into Europe from South America by the Jesuits at the beginning of the 17th century, quinine has been one of the most effective drugs for the treatment of malaria. During this century a number of synthetic antimalarial drugs have been introduced but while these have had considerable success their extensive and ...
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Abstract Since it was introduced into Europe from South America by the Jesuits at the beginning of the 17th century, quinine has been one of the most effective drugs for the treatment of malaria. During this century a number of synthetic antimalarial drugs have been introduced but while these have had considerable success their extensive and ...
openaire +3 more sources
Antiviral Research, 2006
Almost 30 years ago it was proposed that the selection for antiviral drug resistance should be used as an indicator of antiviral drug activity. In addition to discriminating between cellular toxicity and specific activity directed against a viral target, drug resistant mutants have been used to confirm the mechanism of action of antiviral drugs, to ...
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Almost 30 years ago it was proposed that the selection for antiviral drug resistance should be used as an indicator of antiviral drug activity. In addition to discriminating between cellular toxicity and specific activity directed against a viral target, drug resistant mutants have been used to confirm the mechanism of action of antiviral drugs, to ...
openaire +3 more sources
Drug resistance in ostertagiasis
Veterinary Parasitology, 1988Benzimidazole- and levamisole-resistant Ostertagia circumcincta from sheep have been reported from several countries, but there are no reports of anthelmintic-resistant O. ostertagi in cattle, where resistance has been confirmed in controlled trials.
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Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward
Ca-A Cancer Journal for Clinicians, 2021Amila K Nanayakkara +2 more
exaly