Results 171 to 180 of about 8,234,457 (404)

Uncertainty characterisation in action potential modelling for cardiac drug safety

, 2018
Ross H. Johnstone
openalex   +2 more sources

Enhancing Psychiatric Drug Safety: Lessons from Pharmacogenomic Studies of Hypersensitivity Reactions [PDF]

, 2021
Paolo Rinaldi, Marco De Luca, Federico Neri   +2 more
openalex   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Chinese expert consensus on the management of adverse reactions to HER2-targeted antibody-drug conjugates in digestive system cancers (2025 edition)

Zhongguo Linchuang Yixue
Digestive system cancers are very prevalent globally. Among these, human epidermal growth factor receptor 2 (HER2)-positive gastric cancer, colorectal cancer, and cholangiocarcinoma are tumors that require particular attention.
Committee on Antitumor Drug Safety Management, Chinese Society of Clinical Oncology (CSCO) Expert
doaj   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

drug safety

Citation: 'drug safety' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12649 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

A Critical Examination of the FDA’s Efforts to Preempt Failure-to-Warn Claims [PDF]

, 2007
This article explores the legality and wisdom of the FDA’s effort to persuade courts to find most failure-to-warn claims preempted. The article first analyzes the FDA’s justifications for reversing its long-held views to the contrary and explains why ...
Kessler, David A., Vladeck, David C.
core   +1 more source

Comparative clinical evaluation of safety and efficacy of commonly used drug-eluting stents in coronary artery disease patients after angioplasty in South India: A retro-prospective multi-center study [PDF]

, 2019
Vinoth Prabhu Veeramani, Saranya Selvam, Ahmed M. Hamdan, Vinoth Prabhu Veeramani, M Barton, J Gruntzig, M Husmann, J Rosch, E Benjamin, M Blaha, S Chiuve, M Cushman, S Das, R Deo, S De Ferranti, J Floyd, M Fornage, C Gillespie, C Isasi, M Jimenez, L Jordan, S Judd, D Lackland, J Lichtman, L Lisabeth, S Liu, C Longenecker, R Mackey, K Matsushita, D Mozaffarian, M Mussolino, K Nasir, R Neumar, L Palaniappan, D Pandey, R Thiagarajan, M Reeves, M Ritchey, C Rodriguez, G Roth, W Rosamond, C Sasson, A Towfighi, C Tsao, M Turner, S Virani, J Voeks, J Willey, J Wilkins, J Wu, H Alger, S Wong, P Muntner, J Feinberg, E Nielsen, J Greenhalgh, J Hounsome, N Sethi, S Safi, C Gluud, J Jakobsen, R Gupta, W Kim, S Lee, S Park, Y Kim, S Yun, J Lee, D Park, S Kang, C Lee, J Lee, S Choi, I Seong, B Lee, N Lee, Y Cho, W Shin, S Lee, S Lee, M Hyon, D Bang, W Park, H Kim, J Chae, K Lee, H Park, C Park, S Lee, M Kim, K Park, Y Choi, S Cheong, T Yang, J Jang, S Her, S Park, P Karjalainen, A Ylitalo, J Airaksinen   +99 more
openalex   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Structure-mutagenicity relationships on quinoline and indole analogues in the Ames test

Genes and Environment
Background Although the in silico predictive ability of the Ames test results has recently made remarkable progress, there are still some chemical classes for which the predictive ability is not yet sufficient due to a lack of Ames test data.
Masaki Kurakami, Atsushi Hakura, Rika Sato, Akihiro Kawade, Takeshi Yamagata, Naoki Koyama, Dai Kakiuchi, Shoji Asakura   +7 more
doaj   +1 more source