Results 121 to 130 of about 942,716 (313)

The application of the fragment-based screening approach to RmlA protein and PA1645 structure

, 2014
P. aerguinosa is a serious human bacterial pathogen. This thesis describes attempts to use structural biology to identify new starting points for drugs against P.
Boulkeroua, Wassila Abdelli
core  

Structure‐based design of antibodies targeting the EBNA1 DNA‐binding domain to block Epstein–Barr virus latent infection and tumor growth

MedComm
The Epstein–Barr virus (EBV) nuclear antigen 1 (EBNA1) is critically involved in maintaining episomes during latent infection and promoting tumorigenesis.
Yongyue Han, Fang Wu, Ying Zhang, Jun Liu, Yuzhe Wu, Yuecheng Wang, Xiwen Jiang, Xin Chen, Wei Xu   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Is Emerging Nanomedicine a Friend or Foe to Germ Cells?

International Journal of Nanomedicine
Hui Yu,1,2,* Chunhui Hu,3,* Xuelin Wang,1 Ying Zhang,1 Nanhui Zhang,1 Pengxia Yu,1,2 Kai Lian,1 Jiaolong Huang,1 Peng Duan1,2 1Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Xiangyang City, Xiangyang No.
Yu H, Hu C, Wang X, Zhang Y, Zhang N, Yu P, Lian K, Huang J, Duan P   +8 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Complete Automation of Cell Culture: Improvements for High-Throughput and High-Content Screening

, 2011
Genomic approaches provide enormous amounts of raw data with regard to genetic variation, the diversity of RNA species, and protein complement.
Caminada, D., Rizzu, P., Bochdanovits, Z., Shushant Jain, Peter Heutink, Sondervan, D., Zoltan Bochdanovits, David Sondervan, Jain, S., Patrizia Rizzu, Heutink, P., Daniel Caminada   +11 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Automated drug screening of dried blood spots using online LC-MS/MS analysis

, 2020
2 figuras, 2 tablasA fully automated method for the effective drug screening of large populations based on dried blood spot (DBS) technology is presented.
Cebolla, Vicente L., Grill, Matthias, Gaugler, Stefan Christian, Rykl, Jana   +3 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Stem cell secretome armed magneto-actuated micromotors as spatio-temporal manipulators for wound healing acceleration

Nature Communications
Healing complex wounds, especially deep injuries, requires therapies that can target different healing phases while penetrating physical barriers like fibrin clots and scab. Existing approaches fail to fully address these spatiotemporal challenges due to
Jiamiao Jiang, Haiying Liang, Yicheng Ye, Weichang Huang, Jiajun Miao, Haixin Tan, Ziwei Hu, Hao Tian, Hanfeng Qin, Xiaoting Zhang, Lishan Zhang, Junbin Gao, Xian Shen, Shuanghu Wang, Fei Peng, Yingfeng Tu   +15 more
doaj   +1 more source