Results 171 to 180 of about 1,261,260 (337)
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Development and Application of an Automated Solution Stability Assay for Drug Discovery [PDF]
, 2006 Li Di +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
THE IMPORTANCE OF CHROMATOGRAPHICALLY PURIFIED EXCIPIENTS
Разработка и регистрация лекарственных средств, 2019 In the present work critical importance and benefits of Super Refined excipients for drug stability, integrity and safety are described. It was shown, that impurities can disrupt API and cause cell irritation.
G. J. Rizzo, K. H. Chen
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Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Investigations of the effect of the lipid matrix on drug entrapment, in vitro release, and physical stability of olanzapine-loaded solid lipid nanoparticles [PDF]
, 2007 K. Vivek +2 more
openalex +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Multi-access drug delivery network and stability
International Journal of Nanomedicine, 2011 S Mitatha1, N Moongfangklang1, MA Jalil2, N Suwanpayak3, J Ali4, PP Yupapin31Hybrid Computing Research Laboratory, Faculty of Engineering, King Mongkut’s Institute of Technology Ladkrabang, Bangkok, Thailand; 2Ibnu Sina Institute of Fundamental
Ali J +5 more
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