Results 211 to 220 of about 5,501,792 (312)

Patient-derived xenografts: Practical considerations for preclinical drug testing. [PDF]

Hemasphere
de Bock CE.
europepmc   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Patient and Provider Perspectives on the Elimination of Urine Drug Testing in Office-Based Addiction Treatment. [PDF]

Subst Use Addctn J
Theisen J, Weinstein ZM, Davoust M, Ventura AS, Magane KM, Cheng A, Blakemore S, Blodgett J, Fielman S, Saitz R, Bazzi AR.   +10 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

The "yeast-drop" treatment protocol in the <i>Drosophila</i> model for rapid and cost-effective TB drug testing. [PDF]

Front Tuberc
Vidal M, Fuentes E, Escobar N, Arch M, Cardona PJ.   +4 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Detection of ADB-4en-PINACA metabolite in the authentic urine samples

Emerging Trends in Drugs, Addictions, and Health
Ching Yee Fong, Hooi Yan Moy
doaj   +1 more source

Fabrication of cell culture hydrogels by robotic liquid handling automation for high-throughput drug testing. [PDF]

Commun Eng
Torchia E, Di Sante M, Horda B, Mihajlovic M, Zimmermann J, Pezzotti M, Cimetta E, Gabriele S, Auricchio F, Lind JU, Enrico A, Pasqualini FS.   +11 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Lung organoids as a human system for Mycobacteria infection modeling and drug testing. [PDF]

FEBS J
Leon-Icaza SA, Vergé R, Mazars R, Berry L, Cougoule C.   +4 more
europepmc   +1 more source