Results 241 to 250 of about 5,501,792 (312)

Personalizing colorectal Cancer treatment: Chemotherapy drug testing with patient-derived tumor cell clusters. [PDF]

Transl Oncol
Qiu X, Li R, Zhou J, Li P, Xie G, Yin S, Yang L, Lin G.   +7 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Low-cost robotic manipulation of live microtissues for cancer drug testing. [PDF]

Sci Adv
Stepanov I, Gottshall NR, Ahmadianyazdi A, Sinha D, Lockhart EJ, Nguyen TNH, Hassan S, Horowitz LF, Yeung RS, Gujral TS, Folch A.   +10 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

A pro-angiogenic and hypoxic zebrafish model as a novel platform for anti-angiogenic drug testing. [PDF]

Biol Open
S V, Santhakumar K.
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Fenfluramine: An Uncommon Cause of False Positive Urine Drug Testing: A Case Report. [PDF]

Ann Child Neurol Soc
Ghawji M, Hainlen M, Joshi C.
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Variable expression of hepatic genes in different liver tumor cell lines: conclusions for drug testing. [PDF]

Front Cell Dev Biol
Wisniewska MJ, Wencel A, Jakubowska M, Motyl JA, Dudek K, Burzynska B, Pijanowska DG, Pluta KD.   +7 more
europepmc   +1 more source

Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing. [PDF]

Neuro Oncol
van Bree N, Oppelt AS, Lindström S, Zhou L, Boutin L, Coyle B, Swartling FJ, Johnsen JI, Bräutigam L, Wilhelm M.   +9 more
europepmc   +1 more source