Results 281 to 290 of about 4,947,330 (332)

Approaches to improve drug tolerance and target tolerance in the assessment of neutralizing anti-drug antibodies.

Bioanalysis, 2019
Aim: Neutralizing anti-drug antibody (NAb) assays are inherently prone to the interference from drug and its soluble target, potentially resulting in erroneous results.
Bonnie Wu, Megan Schnarr, James L. Devlin, Samantha L Brown, Tong-yuan Yang   +4 more
semanticscholar   +1 more source

Cholinergic drug interactions and heat tolerance

Life Sciences, 1994
Acute, subchronic and chronic exposures to cholinergic compounds may result in differing effects. The efficacy of pyridostigmine bromide (PY) prophylaxis against organophosphorus poisoning depends on post exposure atropine (AT) administration. AT induces a dose-dependent increase in rate of rise of core temperature in heat exposed humans and rats.
C B, Matthew, J F, Glenn, W D, Bowers, D K, Navara   +3 more
openaire   +2 more sources

Tolerance to Drugs, especially to Morphine

Nature, 1960
VARIOUS theories have been put forward to elucidate the development of tolerance to a drug. For example, it has been observed by Zauder1 that “as tolerance develops (in the rat), the amount of morphine appearing in the urine decreases”. This was in accordance with Gross and Thomson's observations on the dog2. Cochin et al.
G, NADEAU, G, SOBOLEWSKI
openaire   +2 more sources

Drug-Induced Disorders of Glucose Tolerance

Annals of Internal Medicine, 1993
To review the medications that influence glucose metabolism and to examine the mechanisms of these medications on glucose metabolism.Data were obtained from a MEDLINE search back to 1966 and included animal and human studies published in the English language.Approximately 80% of original publications were included after review by the authors.
M K, Pandit, J, Burke, A B, Gustafson, A, Minocha, A N, Peiris   +4 more
openaire   +2 more sources

The relation between drug exposure and tolerance: contingent drug tolerance reexamined

2009
The finding that the performance of a response during periods of drug exposure facilitates the development of tolerance to the effects of the drug on that response is commonly referred to as contingent drug tolerance. Contingent tolerance is typically demonstrated in before-and-after design experiments.
openaire   +1 more source

Drug tolerance and biomembranes.

Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1978
Our understanding of the structure and function of biomembranes is now at a stage where we can begin to examine drug actions on the membrane bilayer. Cells need a certain optimal degree of fluidity in their membranes and some organisms can adapt their membrane composition to maintain the appropriate fluidity under changing environmental conditions ...
J H, Chin, D B, Goldstein
openaire   +1 more source

Drug Tolerance and Sensitization

1989
Any reader of this book who is familiar with the reviews on alcohol and drug tolerance published during the 1970s cannot help but be struck by the marked elaboration of knowledge and concepts concerning tolerance that have taken place in the past 10–15 ys. This is particularly true of the behavioral aspects of the subject.
openaire   +1 more source

Drug resistance and drug tolerance in parasites

Trends in Parasitology, 2006
In their recent Trends in Parasitology article on tolerance and antimalarial drug resistance, Hastings and Watkins [1xTolerance is the key to understanding antimalarial drug resistance. Hastings, I.M. and Watkins, W.M. Trends Parasitol. 2006; 22: 71–77Abstract | Full Text | Full Text PDF | PubMed | Scopus (50)See all References][1] made the extremely ...
openaire   +1 more source

Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies

Ca-A Cancer Journal for Clinicians, 2022
Paolo Tarantino, Roberto Carmagnani Pestana, Shanu Modi   +2 more
exaly  

Mechanism of Drug Addiction and Drug Tolerance

Nature, 1941
IT has been found that prolonged administration of ‘luminal’ (and other barbiturates) to human beings (for example, epileptics) and animals greatly reduces the cholinesterase activity of the serum, so that it reaches 10–20 per cent of what it was before the treatment with the drug.
openaire   +1 more source