Results 261 to 270 of about 345,035 (349)

Overcoming resistance to antibody-drug conjugates: mechanisms and emerging strategies. [PDF]

Oncologist
Inase A, Kimbara S, Imamura E, Phelps MA, Minami H.   +4 more
europepmc   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

BEHIND CLOSED DOORS: A QUALITATIVE EXAMINATION OF CONTRABAND DISPOSAL PRACTICES BY AUTHORITIES IN THE FIGHT AGAINST DRUG TRAFFICKING

Rhem Rick N. Corpuz
openalex   +1 more source

Targeting endosomal trafficking-mediated antigen escape to resensitize myeloma to CAR-T therapy. [PDF]

J Immunother Cancer
Wang Z, Wang G, Liu Y, Zhao Y, Guo S, Yang Y, Zhang Q, Hu C, Chang S, Wu X, An D, Hu H, Cai H, Zhang L, Shi J.   +14 more
europepmc   +1 more source

Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy

Advanced Science, EarlyView.
A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru, Priyanka Bhattacharyya, Mingxu You   +2 more
wiley   +1 more source

The Alaska Misconduct Involving Weapons Statutes: A History and Analysis [PDF]

, 2003
Fred, John D.
core   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Comparison of Digital Forensic Tools for Drug Trafficking Cases on Instagram Messenger using NIST Method

Muhammad Fahmi Mubarok Nahdli, Imam Riadi, Muhammad Kunta Biddinika   +2 more
openalex   +2 more sources

A 3D microfluidic model of exchange between perfused blood and lymphatic microvascular networks.

Lab Chip
Gray-Scherr D, Ching T, Beran K, Adams SC, Davis E, van Steen ACI, Raman T, Wong WW, Eyckmans J, Chen CS.   +9 more
europepmc   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source