Results 291 to 300 of about 4,232,654 (389)

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source

Host Cell Virus Interactions: Molecular Mechanisms, Immune Modulation, Viral Pathogenesis, and Emerging Therapeutic Targets. [PDF]

Viruses
Alanazi A, Ibrahim MN, El Azab EF, Elithy MA.   +3 more
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Hijacking exosome biogenesis: viral glycoproteins as modular scaffolds for engineering functionalized extracellular vesicles.

Nanoscale
Levy D, Wang D, Afzali H, Do MA, Zhang J, Flojo R, Ku J, Asano K, Diebold D, Wang A, Lu B.   +10 more
europepmc   +1 more source

New Mechanisms for Regulation of Intracellular Collagen Degradation in Fibrotic Lesions of Periodontal Tissues. [PDF]

FASEB J
Wong WH, Zirngibl RA, Manolson MF, McCulloch CA.   +3 more
europepmc   +1 more source

Virus infection and vesicle trafficking. [PDF]

Front Immunol
Cao GX, Liu FX, Meng CC, Ding C, Dai J, Qiu XS.   +5 more
europepmc   +1 more source

BEHIND CLOSED DOORS: A QUALITATIVE EXAMINATION OF CONTRABAND DISPOSAL PRACTICES BY AUTHORITIES IN THE FIGHT AGAINST DRUG TRAFFICKING

Rhem Rick N. Corpuz
openalex   +1 more source

Contrabando Y Corrupcion: The Rise in Popularity of Narcocorridos [PDF]

, 2001
Fernández, Celestino, Holscher, Louis M.   +1 more
core   +1 more source

The AP-1 Sigma Subunit Gene <i>PsAP1</i> Acts as a Key Pathogenicity Factor by Regulating Metabolic Reprogramming in <i>Puccinia striiformis</i> f. sp. <i>tritici</i>. [PDF]

J Fungi (Basel)
Liu B, Wu J, Zhang G, Chen J, Li G, Wang X, Fernando WGD, Gao H, Li Y.   +8 more
europepmc   +1 more source

Shaping the competence of Europol. An FBI perspective [PDF]

, 2010
De Moor, Alexandra, Vermeulen, Gert
core