Results 201 to 210 of about 579,008 (311)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Structural insights into drug transport by an aquaglyceroporin. [PDF]

Nat Commun
Chen W, Zou R, Mei Y, Li J, Xuan Y, Cui B, Zou J, Wang J, Lin S, Zhang Z, Wang C.   +10 more
europepmc   +1 more source

Mathematical Model of Macromolecular Drug Transport in a Partially Liquefied Vitreous Humor. [PDF]

J Heat Transfer, 2022
Khoobyar A, Penkova AN, Humayun MS, Sadhal SS.   +3 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Cryo-EM of human P-glycoprotein reveals an intermediate occluded conformation during active drug transport. [PDF]

Nat Commun
Culbertson AT, Liao M.
europepmc   +1 more source

Allosteric drug transport mechanism of multidrug transporter AcrB. [PDF]

Nat Commun, 2021
Tam HK, Foong WE, Oswald C, Herrmann A, Zeng H, Pos KM.   +5 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

A literature review of drug transport mechanisms during lactation. [PDF]

CPT Pharmacometrics Syst Pharmacol
Gong C, Bertagnolli LN, Boulton DW, Coppola P.   +3 more
europepmc   +1 more source

Modeling the Effects of Disease, Drug Properties, and Material on Drug Transport From Intraocular Lenses. [PDF]

Transl Vis Sci Technol, 2022
Clasky DP, Meunier L, Wells LA.
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source