Results 81 to 90 of about 579,008 (311)
Drug Delivery, 2017 The intraperitoneal (IP) administration of chemotherapy is an alternative treatment for peritoneal carcinomatosis, allowing for higher intratumor concentrations of the cytotoxic agent compared to intravenous administration. Nevertheless, drug penetration
Margo Steuperaert +6 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Drug Delivery, 2019 Although intraperitoneal chemotherapy (IPC) has evolved into an established treatment modality for patients with peritoneal metastasis (PM), drug penetration into tumor nodules remains limited.
Margo Steuperaert +7 more
doaj +1 more source
High-Throughput Dissolution/Permeation Screening —A 96-Well Two-Compartment Microplate Approach
Pharmaceutics, 2019 Early formulation screening can alleviate development of advanced oral drug formulations, such as amorphous solid dispersions (ASDs). Traditionally, dissolution is used to predict ASD performance.
Ann-Christin Jacobsen +3 more
doaj +1 more source
Successful use of axonal transport for drug delivery by synthetic molecular vehicles
, 2008 We report the use of axonal transport to achieve intraneural drug delivery. We constructed a novel tripartite complex of an axonal transport facilitator conjugated to a linker molecule bearing up to a hundred reversibly attached drug molecules.
Mark Bacon +12 more
core
, 2013 Human hepatocytes are the gold standard for toxicological studies but they have several drawbacks, like scarce availability, high inter-individual variability, a short lifetime, which limits their applicability.
Jemnitz, Katalin +9 more
core +1 more source
Transcriptional regulation and impact of ABC-transporters in intestinal cell lines [PDF]
, 2009 The intestine has an important role in facilitating and limiting absorption of drugs. Since the intestine forms a barrier to the external, epithelial cells have several properties to protect the body from microorganisms and toxins, and to control uptake ...
Maier, Angelika Erika
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
CPT: Pharmacometrics & Systems PharmacologyPhysiologically based pharmacokinetic (PBPK) modeling of placental drug transfer is an evolving tool for predicting fetal drug exposure. In this study, a pregnancy‐specific metformin PBPK model was developed, and the following four approaches were ...
Jacqueline B. Tiley +5 more
doaj +1 more source
Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles
, 2004 The study reports the initial biological evaluation of targeted polymeric glycol chitosan vesicles as carrier systems for doxorubicin (Dox). Transferrin (Tf) was covalently bound to the Dox-loaded palmitoylated glycol chitosan (GCP) vesicles using ...
Dufès, Christine +5 more
core +1 more source