Results 171 to 180 of about 8,164,322 (359)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Electronic data sources for drug utilization research and healthcare decision-making in Mexico. [PDF]

BMC Health Serv Res
Santa-Ana-Tellez Y, Dreser Mansilla A, Castro Pastrana LI, Salas M, Sánchez Salgado JC, Gómez-Galicia D, Freitas Leal L, Cruz Lopes L.   +7 more
europepmc   +1 more source

Age and Gender Trends in Prescribing and Utilization of Lipid-Lowering Drugs at a Public Hospital in Alkharj City

, 2020
Nehad J. Ahmed, Menshawy A. Menshawy, Ziyad S. Almalki, Mohammed Abdulrahman Alhajri   +3 more
openalex   +2 more sources

Comprehensive drug utilization review in neonates: liposomal amphotericin B

The Journal of pharmacy and pharmacology, 2018
Chirlie Silver, Sara E. Rostas
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Care pathway in patients after myocardial infarction in Denmark - healthcare and drug utilization. [PDF]

Int J Cardiol Heart Vasc
Flege MM, Kleinschmidt T, Hansen S, Jensen KJ, Jensen HK, Christiansen MK, Merland CO, Petersen J.   +7 more
europepmc   +1 more source

Platform Development for Drug Discovery Utilizing Silkworm towards “Novel Industrial Revolution”

, 2018
Kazuhisa Sekimizu, Kohji Itoh
openalex   +2 more sources

Donor management using a specialized donor care facility is associated with higher organ utilization from drug overdose donors

, 2020
C. Corbin Frye, Jason M. Gauthier, Amit Bery, William D. Gerull, Deniz B. Morkan, Jingxia Liu, M. Shea Harrison, Yuriko Terada, Judith E. van Zanden, Gary F. Marklin, Michael K. Pasque, Ruben G. Nava, Bryan Meyers, Alexander Patterson, Benjamin D. Kozower, Ramsey R. Hachem, Derek E. Byers, Chad A. Witt, Hrishikesh S. Kulkarni, Daniel Kreisel, Varun Puri   +20 more
openalex   +2 more sources

Utilization, Spending, and Prices Trends for Anti-Epileptic Drugs (AEDS) in the U.S. Medicaid Programs: Empirical Data Analysis from 2010 to 2016 [PDF]

, 2018
Xiaomeng Yue, JJ Guo
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source