Results 171 to 180 of about 2,933,736 (305)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Drug Utilization and Safety Profile of Intravenous Iron Isomaltoside 1000 in Cancer Patients With Iron Deficiency Anemia: A Retrospective Study. [PDF]

Cureus
Anil Kumar Purohit KK, Dilip Kumar Halvawala MK.   +1 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Enhancing the Appropriate Use of Vancomycin in Pediatric Patients: The Impact of Drug Utilization Evaluation and Infectious Disease Consultation. [PDF]

Sage Open Pediatr
Pongpatipat C, Boonsathorn S, Chaisavaneeyakorn S, Santanirand P, Techasaensiri C, Apiwattanakul N.   +5 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The Use of Proton Pump Inhibitors Among Adults in Norway-A Nationwide Drug Utilization Study. [PDF]

Pharmacol Res Perspect
Fossmark R, Molnes S, Sagatun L, Salvesen Ø, Spigset O.   +4 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Care pathway in patients after myocardial infarction in Denmark - healthcare and drug utilization. [PDF]

Int J Cardiol Heart Vasc
Flege MM, Kleinschmidt T, Hansen S, Jensen KJ, Jensen HK, Christiansen MK, Merland CO, Petersen J.   +7 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Electronic data sources for drug utilization research and healthcare decision-making in Mexico. [PDF]

BMC Health Serv Res
Santa-Ana-Tellez Y, Dreser Mansilla A, Castro Pastrana LI, Salas M, Sánchez Salgado JC, Gómez-Galicia D, Freitas Leal L, Cruz Lopes L.   +7 more
europepmc   +1 more source