Results 111 to 120 of about 82,737 (314)

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T. Matschke, Richard Bertz, Robert Croop, Jing Liu   +6 more
wiley   +1 more source

Prospects and Challenges of Medicinal Plants Conservation and\ud Traditional Medicine in Tanzania [PDF]

, 2013
A qualitative study was carried to assess prospects and challenges of medicinal plants conservation and\ud traditional medicine in Tanzania. The study shows that TRM and medicinal have great prospects in healthcare\ud delivery worldwide.
Kayombo, Edmund J, Mahunnah, Rogasian L A, Uiso, Febronia C   +2 more
core  

Activating Ferroptosis of M1 Macrophages: A Novel Mechanism of Asiaticoside Encapsuled in GelMA for Anti‐Inflammation in Diabetic Wounds

Exploration, EarlyView.
Asiaticoside (AS) has known anti‐inflammatory effects in diabetic wounds, but the underlying mechanisms are still unclear. In this study, we reveal that AS alleviates inflammation in diabetic wounds by activating ferroptosis of M1 macrophages, which is attributed to the downregulation of ferroportin 1 and ferritinophagy‐induced degradation of ferritin ...
Shengnan Cui, Sheng Meng, Yong Liu, Shengqiu Chen, Wenzhi Hu, Qilin Huang, Ziqiang Chu, Weicheng Zhong, Liqian Ma, Zhe Li, Yufeng Jiang, Xi Liu, Xiaobing Fu, Cuiping Zhang   +13 more
wiley   +1 more source

Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice

Exploration, EarlyView.
1. Caffeic acid (CA) is a novel senomorphic. 2. Annexin A5 is the direct protein target of CA in senescent cells. 3. The covalent binding of CA to Annexin A5 protein triggers its degradation, PKCθ deactivation, and the inhibition of the NF‐κB inflammatory pathway. 4. CA effectively alleviates inflammation and lung fibrosis in mouse model.
Yinhua Zhu, Ying Zhang, Qianyu Zhang, Ping Song, Junzhe Zhang, Ang Ma, Chen Wang, Peng Gao, Tong Yang, Lirun Zhou, Qiaoli Shi, Yin Kwan Wong, Yongting Luo, Huan Tang, Jigang Wang   +14 more
wiley   +1 more source

Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis

Exploration, EarlyView.
NaCr promotes KCr to impede the inflammatory progression of ulcerative colitis. KCr induces mitophagy by activating the PINK1/PARKIN pathway to restrict NLRP3 inflammasome activation, thereby decreasing the production and release of various inflammatory cytokines, such as IL‐1β and TNF‐α. KCr induces mitophagy and inhibits NLRP3 inflammasome activation
Tongtong Liu, Binyan Lin, Ying Zhang, Jiayu Su, Xiaochao Hu, Xuan Wang, E‐Hu Liu, Shijia Liu   +7 more
wiley   +1 more source

Development of Chinese herbal medicine for sensorineural hearing loss

Acta Pharmaceutica Sinica B
According to the World Health Organization's world report on hearing, nearly 2.5 billion people worldwide will suffer from hearing loss by 2050, which may contribute to a severe impact on individual life quality and national economies.
Yunhao Wu, Jingwen Zhang, Qiuping Liu, Zhuang Miao, Renjie Chai, Wenyong Chen   +5 more
doaj   +1 more source

Increased Risks of Upper Tract Urothelial Carcinoma in Male and Female Chinese Herbalists

Journal of the Formosan Medical Association, 2011
It has been shown that herbs that contain aristolochic acid induce urological cancer. Chinese herbalists have easy access to such herbs. Our previous mortality study has shown a significantly increased risk of urological cancer in female but not male ...
Hsiao-Yu Yang, Jung-Der Wang, Tsai-Chang Lo, Pau-Chung Chen   +3 more
doaj   +1 more source

Physicochemical Properties and Antioxidant Activity of Apocynum Honey in Different Regions of Xinjiang

Food Chemistry International, EarlyView.
ABSTRACT In this study, honey produced from Apocynum venetum L. was collected from BC (Bachu County), SY (Shaya County), and YL (Yuli County) in Xinjiang. The basic physical and chemical properties of the honey, and the contents of total phenols, total flavonoids, and amino acids were analyzed, and 16 types of polyphenols were quantified using triple ...
Na Zhang, Jingjing Lv, Ruili Zhang, Qinghua Jia, Tiantian Jian, Yawen Li   +5 more
wiley   +1 more source

Drug discovery from Chinese medicine against neurodegeneration in Alzheimer's and vascular dementia

Chinese Medicine, 2011
Alzheimer's disease and vascular dementia are two major diseases associated with dementia, which is common among the elderly. While the etiology of dementia is multi-factorial and complex, neurodegeneration may be the major cause of these two diseases ...
So Kwok-Fai, Ho Yuen-Shan, Chang Raymond
doaj   +1 more source

Rutaceae Zanthoxylum–Derived 7‐Demethylsuberosin Alleviates the Rheumatoid Arthritis Through Inhibiting the Maturation of Dendritic Cells via Targeting MAPK14 Functional Food‐Based 7‐Demethylsuberosin

Food Frontiers, EarlyView.
This study revealed that 7‐demethylsuberosin exhibits immunosuppressive effects both in vivo and in vitro. Furthermore, it inhibits the phosphorylation of MAPK14 by targeting it, thereby modulating dendritic cell (DC) maturation and function and reducing inflammation across various in vivo models.
Peng Han, Bo Wang, Luyang Han, Yanbo Zhu, Jiawei Dong, Yuekang Xu, Xiaoying Liu, Jinyao Li   +7 more
wiley   +1 more source