Results 161 to 170 of about 181,905 (281)

Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgenic mice

open access: yesNeuroprotection, EarlyView.
Downregulation of the expression of silent information regulator sirtuin 1 (SIRT1) exacerbates neuronal degeneration and loss by activating forkhead box O1 (FOXO1) acetylation and promoting endoplasmic reticulum stress (ERSA)‐mediated apoptosis in aging.
Nan Zhang   +20 more
wiley   +1 more source

Nontargeted Metabolomic Profiling of a Single Paeonia Lactiflora Plant and its Quality Marker Identification

open access: yesChemistryOpen, EarlyView.
This study employs nontargeted metabolomics to provide a comprehensive chemical profile of one single Paeonia lactiflora plant using liquid chromatography‐mass spectrometry. A total of 214 compounds are identified, including 45 previously unreported metabolites.
Lanmeng Yan   +6 more
wiley   +1 more source

Decoding herbal combination models through systematic strategies: insights from target information and traditional Chinese medicine clinical theory. [PDF]

open access: yesBrief Bioinform
Wang M   +16 more
europepmc   +1 more source

Chemical Characterization, Antioxidant and Enzyme‐Inhibitory Activities of Different Extracts from Three Phlomis Species

open access: yesChemistryOpen, EarlyView.
The tested Phlomis species are a rich source of bioactive molecules with potential therapeutic applications, and selecting appropriate extraction solvents is crucial for achieving the targeted biological activity. Phlomis species (family Lamiaceae) are highly valued as food and herbal medicine.
Sakina Yagi   +8 more
wiley   +1 more source

Development of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells

open access: yesPhytochemical Analysis, EarlyView.
Abstract Introduction Osteoporosis, one of the common bone diseases, manifests itself as a decrease in bone mass. Recently, the use of medicinal plants in the search for effective and low‐toxicity therapeutics for the prevention or treatment of osteoporosis has become a trending topic.
Sibel Kaymak   +6 more
wiley   +1 more source

Targeted Isolation of Coumarins From Sideritis Species Based on Antiviral Screening and Untargeted Metabolomics

open access: yesPhytochemical Analysis, EarlyView.
ABSTRACT Introduction The SARS‐CoV‐2 pandemic has revealed a deficiency in antiviral agents. Plants, traditionally used for respiratory infections, are valuable sources of antiviral compounds. Such a plant is the Sideritis L. taxa (mountain tea), traditionally used against cold and cough.
Ekaterina‐Michaela Tomou   +5 more
wiley   +1 more source

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