Abstract Aims Tirzepatide and semaglutide demonstrated clinically meaningful weight reduction in people with obesity or overweight and type 2 diabetes (T2D) in SURMOUNT‐2 and STEP 2 clinical trials, respectively. In the absence of head‐to‐head trials, this study compared the efficacy of tirzepatide 10 and 15 mg with semaglutide 2.4 mg using an indirect
Emily R. Hankosky+7 more
wiley +1 more source
Integrating machine learning and human use experience to identify personalized pharmacotherapy in Traditional Chinese Medicine: a case study on resistant hypertension. [PDF]
Qianzi C+11 more
europepmc +1 more source
The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets
Disturbances of the microbiota–gut–brain axis are evident in people with Huntington's disease (HD) and in HD animal models. Here, we provide an overview of how the trillions of microorganisms residing in the gut, their secretory products, and the microbiota–gut–brain axis may contribute to HD pathogenesis.
Millicent N. Ekwudo+2 more
wiley +1 more source
Efficacy of Jiedu formula as adjuvant therapy for early recurrence of hepatocellular carcinoma after radical surgery: a propensity score matching study. [PDF]
Qiuting F+5 more
europepmc +1 more source
Aim The Western Pacific region has the fastest aging population and 38% of the world's diabetes population. It is unknown to what extent medication management recommendations are included for older adults in type 2 diabetes (T2D) clinical practice guidelines (CPGs).
Darshna Goordeen+10 more
wiley +1 more source
Network pharmacology: a crucial approach in traditional Chinese medicine research. [PDF]
Zhai Y+12 more
europepmc +1 more source
Peony callus extract (PCE) is beneficial for skin anti‐ageing and sensitivity induced by UVB radiation, through decreasing the level of inflammatory factors and matrix metalloproteinases. Furthermore, our research indicates that PCE effectively improves the total collagen content in human skin. Abstract Objective The study investigated effects of peony
Yufan Li+9 more
wiley +1 more source
Herbal Interventions in Parkinson's Disease: A Systematic Review of Preclinical Studies. [PDF]
Zhao W+6 more
europepmc +1 more source
Transnational Healthcare Practices Among Migrants: A Concept Analysis
ABSTRACT Aims To present a conceptual definition of transnational healthcare in the context of migrant older adults. Design This article follows the Walker and Avant concept analysis framework to conduct an in‐depth analysis of transnational healthcare.
Kateryna Metersky+11 more
wiley +1 more source
Advancements in herbal medicine-based nanozymes for biomedical applications. [PDF]
Yang M+7 more
europepmc +1 more source