Results 221 to 230 of about 78,417 (296)

Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination

open access: yesBritish Journal of Pharmacology, EarlyView.
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding   +5 more
wiley   +1 more source

Anti‐nociceptive action of leonurine through TRPA1 and TRPV4 channels modulation

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Leonurine, a pseudoalkaloid derived from Leonotis leonurus, has been traditionally used in herbal medicine to alleviate conditions such as headaches and abdominal discomfort. Its therapeutic effects are often attributed to potential antioxidant properties; however, the precise molecular mechanisms remain poorly understood ...
Matilde Marini   +20 more
wiley   +1 more source

Animal medical systems from Apis to apes: history, recent advances and future perspectives

open access: yesBiological Reviews, EarlyView.
ABSTRACT Animal medical systems encompass a wide range of behaviours aimed at maintaining or improving health. It has become clear that these behaviours are not limited to animals treating themselves (self‐medication) but also include the treatment of group members, resulting in the adoption of the more inclusive term “animal medication”.
Michelina Pusceddu   +5 more
wiley   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh   +4 more
wiley   +1 more source

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