Results 241 to 250 of about 219,587 (330)

Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination

British Journal of Pharmacology, EarlyView.
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding, Chengqing Ning, Shao‐Ru Chen, Hao‐Ran Yin, Jing Xu, Ying Wang   +5 more
wiley   +1 more source

Editorial: Natural products and their derivatives in the treatment of inflammatory and autoimmune diseases. [PDF]

Front Immunol
El-Shazly M, Xiao J, Chen J.
europepmc   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh, Nathalie Vermeulen, Carolyn Ee, Helena Teede, Amanda J. Vincent   +4 more
wiley   +1 more source

Oxidative stress modulation in alcohol-related liver disease: From chinese botanical drugs to exercise-based interventions. [PDF]

Front Pharmacol
Zhu Y, Jia Y, Zhang E.
europepmc   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Effective Herbal Cocktail Strategies and Mechanisms in Cancer Treatment. [PDF]

Integr Cancer Ther
He T, Zhang Y, Deng D, Yang Z, Zhu Q, Sun Q, Lu T.   +6 more
europepmc   +1 more source

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, EarlyView.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

From 'traditional' remedies to 'modern' supplements: a systematic review and meta-analysis of pharmaceutical adulteration in weight-loss natural products. [PDF]

Front Pharmacol
Phan DTA, Kongkaew C, Heinrich M, Dao TCM, Vo TH.   +4 more
europepmc   +1 more source

PHARMACOLOGY AND TOXICOLOGY OF HERBAL MEDICINE : SUBACUTE TOXICITY OF COMMONLY USED CHINESE DRUGS

The Journal of Toxicological Sciences, 1998
Hsing-Yi Yang, Chieh-Fu Chen
openaire   +4 more sources

Protective effects of Paeonia suffruticosa callus extract in skin through anti‐inflammation and repair UVB‐induced damage

International Journal of Cosmetic Science, EarlyView.
Peony callus extract (PCE) is beneficial for skin anti‐ageing and sensitivity induced by UVB radiation, through decreasing the level of inflammatory factors and matrix metalloproteinases. Furthermore, our research indicates that PCE effectively improves the total collagen content in human skin. Abstract Objective The study investigated effects of peony
Yufan Li, Jiejun Han, Rongyue Gong, Yuankun Liu, Yu Zhou, Tiangui Gong, Bin Wang, Laidi Zhang, Shuodan Li, Jiayue Chen   +9 more
wiley   +1 more source