Results 91 to 100 of about 9,616,743 (356)

Stemming the Global Trade in Falsified and Substandard Medicines [PDF]

open access: yes, 2013
Drug safety and quality is an essential assumption of clinical medicine, but there is growing concern that this assumption is not always correct. Poor manufacturing and deliberate fraud occasionally compromises the drug supply in the United States, and ...
Buckley, Gillian J.   +2 more
core   +2 more sources

Characterization of HSP90 isoforms in transformed bovine leukocytes infected with Theileria annulata [PDF]

open access: yes, 2016
HSP90 chaperones are essential regulators of cellular function, as they ensure the appropriate conformation of multiple key client proteins. Four HSP90 isoforms were identified in the protozoan parasite Theileria annulata.
Calder, Ewen D.D.   +8 more
core   +2 more sources

Cancer associated fibroblasts: An essential role in the tumor microenvironment

open access: yesOncology Letters, 2017
Fibroblasts in the tumor stroma are well recognized as having an indispensable role in carcinogenesis, including in the initiation of epithelial tumor formation.
Leilei Tao   +4 more
semanticscholar   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu   +8 more
wiley   +1 more source

Analysis of organizational and medical documents and formulary lists regulating medical support of pregnant women

open access: yesZaporožskij Medicinskij Žurnal, 2012
Comparative analysis of WHO Model List of Essential Medicines, “Liste des spécialités pharmaceutiques remboursables aux assurés sociaux” and Ukrainian National Formulary concerning the medicines prescribed in cases of pregnancy complications was ...
M. L. Syatynya, E. O. Kovalenko
doaj   +1 more source

Price Sensitivity of Demand for Prescription Drugs: Exploiting a Regression Kink Design [PDF]

open access: yes
This paper investigates price sensitivity of demand for prescription drugs using drug purchase records for at 20% random sample of the Danish population.
Simonsen, Marianne   +2 more
core  

Immunogenic Modulations Induced by Prospective Anti-Malarial Herbal Extracts in Murine Model [PDF]

open access: yes, 2010
Keeping in view the ever increasing problem of drug resistance and affordability of the antimalarial drugs by the poor mass, herbal medicines can become an important and alternative sustainable strategy for malaria treatment.
Chinmoy Karjee   +11 more
core   +1 more source

Integrated drug profiling and CRISPR screening identify essential pathways for CAR T cell cytotoxicity.

open access: yesBlood, 2019
Chimeric antigen receptor (CAR) T cell therapy has proven effective in relapsed and refractory B cell malignancies, but resistance and relapses still occur.
O. Dufva   +16 more
semanticscholar   +1 more source

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song   +15 more
wiley   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider   +4 more
wiley   +1 more source

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