Results 241 to 250 of about 4,947,726 (309)

Clinical Evaluation of Anaplastic Lymphoma Kinase (ALK) Inhibitors for the First-Line Treatment of Advanced ALK-Positive Non-Small Cell Lung Cancer Based on the 2nd Edition of China's Drug Evaluation and Selection Guideline. [PDF]

Drug Des Devel Ther
Guo Z, Zhang Y, Chen H, Dong X, Lei W, Zhong L, Yang J, Huang H, Chen Z, Liang W.   +9 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

4D nanoimaging-guided smart therapeutics: spatiotemporal control of disease microenvironments. [PDF]

RSC Adv
Sarma AD, Devi M, Webster TJ, Kumar D, Choudhary N, Kondaveeti SB.   +5 more
europepmc   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

New Insights Into Immunomodulatory Strategies for Drug Hypersensitivity Reactions: An EAACI Task Force Report. [PDF]

Clin Transl Allergy
Copaescu AM, Gueli V, Chahuan J, Albalawi W, Sfriso G, Giovannini M, de Las Vecillas L, Karavelia A, Labella M, Fernandez-Santamaria R, Mori F, Garvey LH, Bonadonna P, Torres MJ.   +13 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Development Timelines of Innovative Drugs in China: A 15-Year Cross-Sectional Analysis of Characteristics and Influencing Factors. [PDF]

Clin Transl Sci
Xu M, Wang C, An X.
europepmc   +1 more source

693 drugs in essential drugs list.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1999
openaire   +1 more source

Antiepileptic drug therapy in companion animals: New perspectives on clinical pathology monitoring. [PDF]

Vet Anim Sci
Lotfalizadeh N, Nazifi S.
europepmc   +1 more source

Rational Prescribing Under Pressure: A World Health Organization Indicator and National Medical Commission Compliance Audit With Shift-Based Analysis of Emergency Prescriptions at a Tertiary Care Hospital in North India. [PDF]

Cureus
Kaur B, Goel A, Bharti B, Vashisht T, Lanjewar S, Singh B.   +5 more
europepmc   +1 more source