Results 151 to 160 of about 104,914 (293)

Indirect Comparison of Neoadjuvant Treatment Strategies for Muscle‐Invasive Bladder Cancer: ddMVAC and Perioperative Durvalumab‐Gemcitabine‐Cisplatin Versus Gemcitabine‐Cisplatin: A Systematic Review and Network Meta‐Analysis of Randomised Controlled Trials

International Journal of Cancer, EarlyView.
Optimizing neoadjuvant therapy for muscle‐invasive bladder cancer patients who are eligible for cisplatin remains difficult, owing particularly to high toxicity and recurrence rates. This meta‐analysis compared dose‐dense methotrexate, vinblastine, doxorubicin, and cisplatin (ddMVAC) against durvalumab plus gemcitabine‐cisplatin (D‐GC) and GC alone ...
Maurin Helen Mangold, Gloria Baumann, Victoria Luise Simone Wieland, Nicolas Carl, Luisa Vivienne Renner, Alexander Studier‐Fischer, Hanna Menold, Stefanie Zschäbitz, Frederik Wessels, Niklas Westhoff, Maurice Stephan Michel, Karl‐Friedrich Kowalewski, Caelán Max Haney‐Aubert   +12 more
wiley   +1 more source

Improving Laboratory-Based Cancer Drug Discovery Study Designs for Better Research Translations. [PDF]

Methods Protoc
Manoharan S.
europepmc   +1 more source

Mapping the Global Clinical Landscape of Pharmacological Therapies for Heart Failure With Preserved Ejection Fraction: An Analysis Based on ClinicalTrials.gov (2003–2025)

iMetaMed, EarlyView.
This study analyzed 236 heart failure with preserved ejection fraction (HFpEF) pharmacological trials registered on ClinicalTrials.gov from 2003 to 2025, revealing a post‐2016 surge (76.3%), U.S. dominance (58.5%), and prominence of SGLT2 inhibitors/novel therapies (each 13.1%).
Yucheng Hou, Jingwei Zhao, Yuqian Tang, Tan Liu, Zhiao Zhang, Ziheng Wang, Han Shen   +6 more
wiley   +1 more source

Immune Imbalance in Sickle Cell Anemia: Flow Cytometric Insights Into Regulatory T Cells and Neutrophil Dynamics

Journal of Clinical Laboratory Analysis, EarlyView.
Flow cytometric analysis in sickle cell anemia reveals preserved Treg frequency despite decreased CD25 expression and increased neutrophil activity, highlighting a complex immune imbalance. The proportions of both neutrophil and lymphocyte cells have been shown to be a reliable predictor of CD3+ T cell levels, thus emphasizing the importance of innate ...
Rukiye Ölçüoğlu, Funda Tanrıkulu, Sevtap Kılınç, Eda Çakmak, Süheyl Asma, Can Boğa, Hakan Özdoğu, İlknur Pamuk   +7 more
wiley   +1 more source

Unraveling the molecular landscape of pancreatic cancer: a systems biology approach to identify therapeutic targets. [PDF]

Discov Oncol
Ahmadipour E, Ebrahimi S, Nasri H, Amerizadeh F.   +3 more
europepmc   +1 more source

Therapeutic drug monitoring of voriconazole : validation of a novel ARK™ immunoassay and comparison with ultra-high performance liquid chromatography [PDF]

, 2015
Cattoir, Lien, Degandt, Simon, Fauvarque, Grégoire, Ghys, Timothy, Stove, Veronique, Verstraete, Alain   +5 more
core   +1 more source

Recent Advances in Thalassemia Research: A Comprehensive Assessment From Diagnostic Technologies to Clinical Treatment

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia, a common hereditary blood disorder causing impaired globin synthesis and related complications, has seen remarkable progress in recent years due to advancements in genomics and molecular biology. Researchers have identified various gene variants related to thalassemia and improved clinical diagnostic methods, including new genetic testing ...
Chaoqiong Zhou, Ting Chen, Ying Huang, Huali Wang, Dahai He, Feng Wu, Yan Zhang, Lirui Kong   +7 more
wiley   +1 more source

Regulatory, ethical, and clinical barriers to exosome use in interventional pain medicine. [PDF]

Interv Pain Med
Bourcier AJ, Kirkor ZM.
europepmc   +1 more source

Cytoreductive Surgery in Patients With Metastatic Succinate Dehydrogenase‐Deficient Gastrointestinal Stromal Tumors

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Succinate dehydrogenase‐deficient (SDH‐deficient) gastrointestinal stromal tumors (GIST) are characterized by variable disease biology with poor responses to traditional tyrosine kinase inhibitors. The role of surgical intervention has been highly debated.
Katherine Y. Chen, Mark Antkowiak, Ashwyn K. Sharma, Robert Mallory, Adam M. Burgoyne, Paul T. Fanta, Jason K. Sicklick   +6 more
wiley   +1 more source

Correction: Opportunities for and Challenges of Pulmonary Drug Delivery in the Management of Acute Exacerbations of CNS Disorders. [PDF]

CNS Drugs
Detyniecki K, Strzelczyk A, Roebling R, Laloyaux C, Chanteux H, Cloyd JC.   +5 more
europepmc   +1 more source