Medicines for the Treatment Of COVID-19: Awaiting the Evidence
Acta Médica Portuguesa, 2020 The novel severe acute respiratory syndrome coronavirus 2 is the cause of Coronavirus Disease 2019, a new illness with no effective treatment or vaccine that has reached pandemic proportions.
Natalia Marto, Emília C. Monteiro
doaj +1 more source
Consensus on the Clinical Approach to Moderate-to-Severe Atopic Dermatitis in Spain: A Delphi Survey [PDF]
, 2020 Background. The purpose of this study was to gather information on the current assessment and management of patients with moderate-to-severe AD in routine daily practice. Methods.
Armario Hita, José Carlos +9 more
core +3 more sources
BMC Medical Ethics, 2019 Background Patients with unmet medical needs sometimes resort to non-standard treatment options, including the use of unapproved, investigational drugs in the context of clinical trials, compassionate use or named-patient programs.
Eline M. Bunnik, Nikkie Aarts
doaj +1 more source
Effects of the anti-RANKL antibody denosumab on joint structural damage in patients with rheumatoid arthritis treated with conventional synthetic disease-modifying antirheumatic drugs (DESIRABLE study): a randomised, double-blind, placebo-controlled phase 3 trial. [PDF]
, 2019 ObjectiveTo evaluate the efficacy of denosumab in suppressing joint destruction when added to conventional synthetic disease-modifying antirheumatic drug (csDMARD) therapy in patients with rheumatoid arthritis (RA).MethodsThis was a multi-centre ...
Genant, Harry K +9 more
core +2 more sources
Heliyon, 2021 Safe and effective oral formulation of a drug, that is easy to store, transport, and administer, is imperative to reach the masses including those without adequate facilities and resources, in order to combat globally transmitted coronavirus disease 2019
Chaitanya N. Hiremath
doaj +1 more source
The Ethics of Placebo-controlled Trials: Methodological Justifications [PDF]
, 2013 The use of placebo controls in clinical trials remains controversial. Ethical analysis and international ethical guidance permit the use of placebo controls in randomized trials when scientifically indicated in four cases: (1) when there is no proven ...
Grady, Christine, Millum, Joseph
core +1 more source
Successful private–public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines [PDF]
, 2014 The European Paediatric Regulation mandated the European Commission to fund research on off-patent medicines with demonstrated therapeutic interest for children.
Baiardi, P +17 more
core +1 more source
Mass balance and pharmacokinetics of an oral dose of 14C‐napabucasin in healthy adult male subjects
Pharmacology Research & Perspectives, 2021 This phase 1, open‐label study assessed14C‐napabucasin absorption, metabolism, and excretion, napabucasin pharmacokinetics, and napabucasin metabolites (primary objectives); safety/tolerability were also evaluated.
Xiaoshu Dai +7 more
doaj +1 more source
Medical Management of Pulmonary Arterial Hypertension: Current Approaches and Investigational Drugs
Pharmaceutics, 2023 Pulmonary arterial hypertension (PAH) is a malignant pulmonary vascular syndrome characterized by a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, which eventually leads to right heart failure and even death ...
Qi Jin +9 more
doaj +1 more source
The Case for Legal Regulation of Physicians’ Off-Label Prescribing [PDF]
, 2011 Deafness has been associated with poor abilities to deal with digits in the context of arithmetic and memory, and language modality-specific differences in the phonological similarity of digits have been shown to influence short-term memory (STM ...
Coleman, Doriane Lambelet +1 more
core +2 more sources