Results 181 to 190 of about 6,254,499 (310)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Comparative efficacy of new wake-promoting agents for narcolepsy-a network meta-analysis. [PDF]

BMC Neurol
Yan Z, Li J, Yu Y, Qiu S, Wang B, Tang J.   +5 more
europepmc   +1 more source

The In vitro anti-acne activity of two unani drugs

, 2013
Shahid Chaudhary, Mohd Tariq, Roohi Zaman, Shaikh Imtiyaz   +3 more
openalex   +1 more source

The ototoxic drug cisplatin localises to stress granules altering their dynamics and composition

, 2023
Jack L. Martin, Stephen J. Terry, Jonathan E. Gale, Sally J. Dawson   +3 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Correction: Management of Bipolar Disorder in Pregnancy and Postpartum: A Clinicians' Guide. [PDF]

CNS Drugs
Bergink V, Suleiman M, Hennen MA, Robakis T.   +3 more
europepmc   +1 more source

Risk of Stroke-Associated Pneumonia With Acid-Suppressive Drugs

, 2015
Sai‐Wai Ho, Ming‐Ju Hsieh, Shun‐Fa Yang, Ying‐Tung Yeh, Yu‐Hsun Wang, Chao‐Bin Yeh   +5 more
openalex   +1 more source

Comparing checkerboard, isobologram and CCD methods for drug combination: A case study of ciprofloxacin and plant extracts on Escherichia coli and Shigella

, 2021
Gislaine Aurelie Kemegne, Sylvain Leroy Sado Kamdem, Maximilienne Ascension Nyegue, Chantal Menut, François‐Xavier Etoa   +4 more
openalex   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Five-year follow-up with the incidence of cardiovascular adverse events after prescribing single-pill combination of antihypertensive drugs: retrospective cohort study. [PDF]

J Pharm Health Care Sci
Matsumura M, Nakamura T, Kadoyama K, Yano R, Iwanaga K, Imanishi K, Yamanishi K, Nakakura I, Une Y, Nakamura T.   +9 more
europepmc   +1 more source