Results 101 to 110 of about 5,455,798 (298)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

The Antihypoxic and Sedative Activity of the Dry extract from Asperula odorata L

, 2015
Introduction: Sweet Woodruff (Asperula odorata L.) is a perennial herb that is spread throughout the territory of Ukraine. This herb is widely used in folk medicine of Ukraine as a sedative medicine at neurosis, neurasthenia, hysteria, depression ...
Iurchenko Nataliia Sergeevna, Ilyina Tatyana Vasilevna, Kovaleva Alla Mihaylovna, Toryanik Erica Leonidivna, Kulish Irina Aleksandrovna   +4 more
semanticscholar   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Bioaccessibility of Rosmarinic Acid and Basil (Ocimum basilicum L.) Co-Compounds in a Simulated Digestion Model—The Influence of the Endogenous Plant Matrix, Dose of Administration and Physicochemical and Biochemical Digestion Environment

Molecules
The objective of this study is to determine the effect of endogenous plant matrix components, dose and digestion-related factors on the bioaccessibility of rosmarinic acid and basil co-compounds in in vitro digestion conditions.
Łukasz Sęczyk, Barbara Kołodziej
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

DEVELOPMENT OF TECHNOLOGICAL PROCESSES OF THE DRY EXTRACTS OF MORINDA CITRIFOLIA ROOTS

Разработка и регистрация лекарственных средств, 2019
The aim of this study is to develop the technology of dry extracts from the roots of Morinda citrifolia as a prospective phyto-active pharmaceutical ingredient (API) for obtaining medicinal products.
R. K. Agbadi, I. E. Kaukhova, V. A. Vanshtein, S. A. Minina, M. V. Yakovleva, M. A. Vlasenko, A. Y. Kutlushina   +6 more
doaj  

Effects of the purified dry extract of fermented ginseng BST204 on muscle fiber regeneration. [PDF]

Biochem Biophys Rep, 2023
Jo SI, Park YS, Chang Y, Moon JH, Lee S, Lee H, Kim M, Kim DY, Bae S, Park SY, Yun H, You JE, Im M, Han HJ, Kim SY, Jin DH.   +15 more
europepmc   +1 more source

Freeze-drying: perceptions and challenges for drying foodstuffs and plant extracts

Revista Vitae, 2015
One of the most important features of foodstuffs and plant extract-based products is related to their fragile stability, especially when exposed to several ambient factors such as air, light radiation, heat and water vapour. The latter may contribute to the increase of free or bound water associated to the product. In this scenario, these variables may
SALAMANCA, Constain, ROJAS, John
openaire   +4 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source