Results 71 to 80 of about 5,455,798 (298)
Farmacia, 2018 The aim of our study was the obtaining, phytochemical characterization, evaluation of antioxidant activity and cytotoxic effects of a selective dry extract obtained from indigenous Pelargonium graveolens L’Hér (rose geranium, rose scented geranium ...
A. Neagu
semanticscholar +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Spray drying of liquorice (Glycyrrhiza glabra) extract [PDF]
Journal of Food Science and Technology, 2012 The objective of this work was to study the influence of spray drying conditions on the physicochemical properties of liquorice (Glycyrrhiza glabra) extract. The stickiness and hydroscopicity problems in the power were overcome by use of dextrose equivalent (DE12) and DE19 maltodextrins as drying agents.
İrem, Karaaslan, Ali Coşkun, Dalgıç
openaire +2 more sources
, 2017 Lipase can be produced from Aspergillus niger using solid state fermentation method. This research aimed to produce lipase in powder form. The highest activity unit (38.67 U/g) was obtained from rice bran substrate at 5th day with inducer concentration ...
T. S. Utami +3 more
semanticscholar +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Разработка и регистрация лекарственных средств, 2019 The aim of the study on the development conditions for extraction of a series of three-part herbs, Bidens tripartita L., Solidago canadensis L. and Agrimonia eupatoria L. herbs in the technology of dry extracts. The influence of factors on the process of
I. E. Kaukhova +2 more
doaj
PLoS ONE, 2016 Triterpenes from the outer bark of birch are known for various pharmacological effects including enhanced wound healing (WH). A birch bark dry extract (TE) obtained by accelerated solvent extraction showed the ability to form oleogels when it is ...
I. Steinbrenner +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Ivy leaves dry extract EA 575® decreases LPS-induced IL-6 release from murine macrophages.
Pharmazie, 2016 IL-6 plays a key role in the course of inflammatory processes as well as in the regulation of immune responses by the release of different cytokines. IL-6 is produced e.g.
J. Schulte-Michels +3 more
semanticscholar +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source