Results 111 to 120 of about 129,354 (289)

Features of dry eye syndrome treatment [PDF]

Клиническая офтальмология, 2018
E.A. Egorov Pirogov Russian National Research Medical University, Moscow, Russian Federation Abstract Dry eye syndrome (DES) is a multifactorial disease of eye surface, characterized by a disturbance of tear film homeostasis and accompanied by ...
E.A. Egorov
doaj  

A case with acquired lacrimal fistula due to Sjögren's syndrome

American Journal of Ophthalmology Case Reports, 2019
Purpose: To report a case with lacrimal fistula presumably associated with Sjögren's syndrome. Observations: A patient with Sjögren's syndrome was referred to our hospital for fistula from the inferior lacrimal canaliculus to the palpebral conjunctiva of
Sho Ishikawa, Takuhei Shoji, Yuri Nishiyama, Kei Shinoda   +3 more
doaj   +1 more source

Outcome parameters in studies investigating dry eye disease: A systematic literature review

Acta Ophthalmologica, EarlyView.
Abstract The development of effective therapeutics for dry eye disease (DED) is challenging due to its complex pathophysiology, heterogeneous patient presentation and the significant failure rate of previous clinical development programs. This underlines the importance of the selection of appropriate endpoints for clinical trials.
Viktoria Pai, Doreen Schmidl, Liudmyla Petric, Patrick Janku, Theresa Lindner, Ulrich Graf, Jacqueline Chua, Leopold Schmetterer, Gerhard Garhöfer   +8 more
wiley   +1 more source

Matrix Metalloproteinases and Glaucoma Treatment. [PDF]

, 2020
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade extracellular matrix (ECM) components such as collagen and have important roles in multiple biological processes, including development and tissue remodeling, both in ...
Dibas, Mohammed, Robinson, Michael R, Stamer, W Daniel, Weinreb, Robert N   +3 more
core  

What is the incidence and clinical significance of dry eye disease in patients treated with immune checkpoint inhibitors? A systematic review and meta‐analysis of ocular immune‐related adverse events

Acta Ophthalmologica, EarlyView.
Abstract Purpose Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may cause immune‐related adverse events (irAEs), including dry eye disease (DED). This study aimed to quantify the incidence of ICI‐associated DED and to evaluate factors contributing to variability across studies.
Kai‐Yang Chen, Hoi‐Chun Chan, Chi‐Ming Chan   +2 more
wiley   +1 more source

Randomized, single‐centre, double‐blinded repeated dose investigation of safety and tolerability of ocular administrations of a novel silica eye drop product in healthy volunteers

Acta Ophthalmologica, EarlyView.
Abstract Purpose Managing ocular diseases often requires frequent eye drop administration, which can challenge patient compliance. A long‐acting eye drop technology using an amorphous synthetic silica composite was developed to address this. Our study aimed to assess the safety and tolerability of the Silica Eye Drop platform in healthy volunteers over
Aleksandra Poluianova, Marceline N. Akieh‐Pirkanniemi, Arto Hartikainen, Hanna Arstila, Kai Kaarniranta, Lasse Leino   +5 more
wiley   +1 more source

Distinctive Mechanisms and Patterns of Exudative Versus Tractional Intraretinal Cystoid Spaces as Seen With Multimodal Imaging. [PDF]

, 2020
PurposeTo determine clear-cut distinctions between tractional and exudative intraretinal cystoid spaces subtypes.DesignRetrospective, multicenter, observational case series.MethodsA cohort of patients diagnosed with intraretinal cystoid spaces and imaged
Au, Adrian, Chehaibou, Ismael, Couturier, Aude, Govetto, Andrea, Grondin, Christelle, Hubschman, Jean-Pierre, Romano, Mario R, Sarraf, David, Tadayoni, Ramin, Virgili, Gianni   +9 more
core  

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

Novel Progress in Limbal Stem Cell Transplantation

Organ Medicine, EarlyView.
Liqin Huang, Liangbo Chen
wiley   +1 more source

The impact of systemic long‐term medications for the development of age‐related macular degeneration

Acta Ophthalmologica, EarlyView.
Abstract Purpose Age‐related macular degeneration (AMD) is a leading cause of central vision loss in the elderly; however, the systemic factors that modulate its incidence and progression remain unclear. We sought to determine whether long‐term use of systemic medications, including diabetes and antithrombotic medications, corticosteroids and ...
Hanna Heloterä, Reijo Sund, Toni Rikkonen, Kai Kaarniranta   +3 more
wiley   +1 more source