Results 171 to 180 of about 97,702 (295)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Efficacy of rebamipide for the treatment of dry eye disease: An updated meta-analysis of randomized and non-randomized controlled trials. [PDF]

Medicine (Baltimore)
Murtaza M, Farooque U, Batool A, Rasool M, Ahmed N, Hafsa Qadri S, Ali Akbar M, Ali S, Patel T, Patel T.   +9 more
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, Volume 13, Issue 32, 9 June 2026.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Matching-adjusted indirect comparison of acoltremon ophthalmic solution 0.003% and cyclosporine 0.05% ophthalmic emulsion for increased tear production in patients with dry eye disease. [PDF]

J Comp Eff Res
Pflugfelder S, Okoro T, Ainslie-Garcia M, Haltner A, Prentiss EK, Salvo-Halloran EM, Srikanth N, Senchyna M, Akpek EK.   +8 more
europepmc   +1 more source

Facilitating Genetic Testing for Perinatal Demise: Development of a Multidisciplinary Workflow

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1273-1285, June 2026.
ABSTRACT Genetic contributors to perinatal demise are common but frequently undiagnosed due to clinical and logistical barriers. We aimed to improve access to genetic for intrauterine fetal demise (IUFD), stillbirth, and early neonatal death by developing a multidisciplinary workflow.
Mackenzie Mosera, Samantha Stover, Elise Boos, Molly Casey, Joseph Fanning, Chelsea Fechter, Matthew Grace, L. Dupree Hatch, Michaela Ibach, Carla Jackson, Jiancong Liang, Caitlin Mann, Emily A. Morris, Jessica Turnbull, Marie Williams, Bryce A. Schuler   +15 more
wiley   +1 more source

Severe nausea and vomiting after teprotumumab initiation with corticosteroid pretreatment: a case report. [PDF]

Int J Ophthalmol
Youn J, Firn K, Hawy E, Van Putten D.
europepmc   +1 more source

Ophiopogonin D Mediates Therapeutic Effects on Primary Sjögren's Syndrome by Modulating Gut Microbiota and Metabolite Profiles

Biomedical Chromatography, Volume 40, Issue 6, June 2026.
ABSTRACT This study aimed to investigate the mechanism of ophiopogonin D (OD) in treating primary Sjögren's syndrome (pSS) through integrated analysis of gut microbiota and metabolomics. Non‐obese diabetic/LtJ mice, a well‐established pSS model, were used as the model group and treated with OD or hydroxychloroquine.
Fengtao Pang, Xueyan Shan, Yi Kong, Xiaopo Tang   +3 more
wiley   +1 more source

Current and Developing Therapeutics for Dry Eye Disease: Targeting Ion Channels. [PDF]

Curr Issues Mol Biol
Jung R, Kao E, Guaiquil VH, Djalilian AR, Rosenblatt MI.   +4 more
europepmc   +1 more source

Bilateral Avascular Necrosis of the Femoral Heads in Ankylosing Spondylitis Requiring Staged Total Hip Arthroplasty: A Case Report of Diagnostic and Therapeutic Challenges

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Ankylosing spondylitis (AS) is a chronic immune‐mediated inflammatory arthropathy primarily affecting the axial skeleton but may involve peripheral joints, particularly the hips. Avascular necrosis (AVN) of the femoral head represents a severe, underrecognized complication whose pathogenesis in AS is multifactorial—encompassing disease ...
Syeda Simrah Shah, Muhammad Ahsan, Tehreem Farooq, Mirza Daniyal Baig, Mirza Mohammad Ali Baig, Mohammed Hammad Jaber Amin   +5 more
wiley   +1 more source

Regenerative Medicine Approaches to Craniofacial and Corneal Neuropathic Pain. [PDF]

Pharmaceuticals (Basel)
Liongson FAZ, Yoo J, Swett B, Falowski SM, Pope JE, Sayed D, Deer TE, Hasoon JJ, Keith DA, Gustaldi FP, Kulich RJ, Robinson CL.   +11 more
europepmc   +1 more source