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Developing Dry Powder Inhaler Formulations
Journal of Aerosol Medicine and Pulmonary Drug DeliveryThis section aims to provide a concise and contemporary technical perspective and reference resource covering dry powder inhaler (DPI) formulations. While DPI products are currently the leading inhaled products in terms of sales value, a number of confounding perspectives are presented to illustrate why they are considered surprisingly, and often ...
David A V, Morton, David, Barling
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Dry Powder Inhalers: From Bench to Bedside
Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2023Dry powder inhalers (DPIs) are now widely prescribed and preferred by the majority of patients. These devices have many advantages over the traditional pressurized metered-dose inhaler (pMDI) but they do have disadvantages. The characteristics of the dose emitted from a DPI are affected by the inhalation manoeuvre used by a patient.
Henry, Chrystyn +2 more
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2016
Pulmonary tract is one of the oldest routes used for administration of drugs. During the past decade, the lung has been very attractive for achieving systemic and local absorption of various drugs, particularly for those drugs that exhibit poor bioavailability when administered by the oral or parenteral route.
Aysu Yurdasiper +3 more
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Pulmonary tract is one of the oldest routes used for administration of drugs. During the past decade, the lung has been very attractive for achieving systemic and local absorption of various drugs, particularly for those drugs that exhibit poor bioavailability when administered by the oral or parenteral route.
Aysu Yurdasiper +3 more
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Exhalation immediately before inhalation optimizes dry powder inhaler use
Journal of Asthma, 2015Although exhalation immediately prior to inhalation (EPI) from dry powder inhalers (DPIs) is universally advised, its benefit has not been investigated. The objective of this study to assess the effects of EPI on inhaled flow from a DPI.We measured peak inhaled flow rate (PIFR) and inhaled gas volume of 25 volunteers unfamiliar with DPIs.
Tetsuri, Kondo +4 more
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Dry-Powder Inhalers in Acute Asthma
Therapeutic Delivery, 2013An updated literature search was performed to evaluate the efficacy of rapid-acting β2-agonists delivered via dry powder inhalers in the treatment of moderate-to-severe acute asthma. Databases were searched from 1985 up to December 2012. A total of 23 randomized, double-blind or open clinical studies in acute asthma comparing the efficacy of a dry ...
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Dry powder inhaler and method for pulmonary inhalation dry powder.
2004A breath actuated dry powder inhaler (1), comprising a substantially disc shaped air circulation chamber (2) for de-agglomeration of entrained powdered medicament using the energy of the inspiratory air stream. The chamber has a substantially circular or polygonal sidewall (3) extending about a central axis (4) between top (5) and bottom walls (6) of ...
de Boer, Anne +2 more
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Dry Powder Inhalers: Advantages and Limitations
Journal of Aerosol Medicine, 1991New inhalers have been developed because of difficulty of using the conventional metered dose inhaler (MDI) and because of the impending ban on CFC's. Dry powder inhalers (DPI's) in general are easier to use than the MDI and cause fewer irritant effects.
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Dry powder inhaler formulation.
Respiratory care, 2005A drug product combines pharmacologic activity with pharmaceutical properties. Desirable performance characteristics are physical and chemical stability, ease of processing, accurate and reproducible delivery to the target organ, and availability at the site of action.
Martin J, Telko, Anthony J, Hickey
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Protein Inhalation Powders: Spray Drying vs Spray Freeze Drying
Pharmaceutical Research, 1999To develop a new technique, spray freeze drying, for preparing protein aerosol powders. Also, to compare the spray freeze-dried powders with spray-dried powders in terms of physical properties and aerosol performance.Protein powders were characterized using particle size analysis, thermogravimetric analysis, scanning electron microscopy, X-ray powder ...
Y F, Maa +4 more
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Dry Powder Aerosols I: A New Powder Inhalation Device
Journal of Pharmaceutical Sciences, 1971Abstract A new portable device is described for administration of powdered drugs by inhalation. Powder contained in a standard hard gelatin capsule is induced to flow from the capsule into the air stream by a vibratory feed mechanism arising from a rotor driven by the inhaled air.
J H, Bell, P S, Hartley, J S, Cox
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