Results 61 to 70 of about 258,865 (310)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Dry matter losses and methane emissions during wood chip storage: the impact on full life cycle greenhouse gas savings of short rotation coppice willow for heat [PDF]
, 2016 A life cycle assessment (LCA) approach was used to examine the greenhouse gas (GHG) emissions and energy balance of short rotation coppice (SRC) willow for heat production.
Whittaker, C. +7 more
core +1 more source
Applied SciencesDuring the decommissioning of the BN-350 reactor, the spent nuclear fuel (SNF) was transferred to long-term dry storage in TUK-123 transport and storage cask systems designed for transportation and long-term storage with a design service life of ...
Yerzhan Sapatayev +5 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
THERMAL ANALYSIS OF DRY STORAGE AND TRANSPORTATION CASKS CASTOR USING COBRA-SFS
Acta Polytechnica CTU Proceedings, 2020 State Office for Nuclear Safety is a regulator body in the Czech Republic handling also licensing of storage and transportation casks (SCs) of the spent nuclear fuel (SNF).
Martin Ševeček +2 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Biomass Dry Storage for Capture and Storage of CO2 and Energy
Proceedings of the 2nd International Conference on Vocational Education and Training (ICOVET 2018), 2019 Carbon dioxide (CO2) and other greenhouse gases (GHG) are considered the main cause of many environmental issues that lead to climate change and global warming.
Z. Mostefaoui Z. Mostefaoui +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source