Results 41 to 50 of about 3,329 (189)

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

Satisfaction with health care among people with differences of sex development (DSD) in Germany

Endocrine Connections
Objective: Individuals with a difference of sex development (DSD) face complex medical and psychosocial challenges, which can make it difficult to provide care tailored to their needs and in line with guidelines.
Maike Schnoor, Andreas Heidenreich, Martina Jürgensen, Ulla Döhnert, Olaf Hiort, Alexander Katalinic, the DSDCare study group   +6 more
doaj   +1 more source

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

Implementation of differentiated service delivery for paediatric HIV care and treatment: opportunities, challenges and experience from seven sub-Saharan African countries

Family Medicine and Community Health, 2020
Differentiated service delivery (DSD) models for HIV often exclude children and adolescents. Given that children and adolescents have lower rates of HIV diagnosis, treatment and viral load suppression, there is a need to use DSD to meet the needs of ...
Anna Grimsrud, Rebecca Abelman, Catharina Alons, Jeni Stockman, Ivan Teri, Maryanne Ombija, Christopher Makwindi, Justine Odionyi, Esther Tumbare, Barry Longwe, Mahoudo Bonou, Juma Songoro, Lawrence Mugumya, Jennifer Cohn   +13 more
doaj   +1 more source

Determining the Minimal Clinically Important Difference of the 40‐Item Smell Identification Test in People With Cystic Fibrosis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) are highly prevalent among people with cystic fibrosis (PwCF) and negatively impact quality of life. The 40‐item Smell Identification Test (SIT) is widely used to assess psychophysical olfaction, but a CF‐specific minimal clinically important difference (MCID) has not been ...
Eugene Oh, Jessa E. Miller, Michelle J. Lee, Anna Zemke, David Baraghoshi, Matthew J. Strand, Jeremiah A. Alt, Todd E. Bodner, Michael Chang, Naweed I. Chowdhury, Patricia H. Eshaghian, Anne E. Getz, Jennifer L. Goralski, David A. Gudis, Peter H. Hwang, Ashoke Khanwalkar, Adam J. Kimple, Jivianne T. Lee, Douglas A. Li, Jess C. Mace, Jayakar V. Nayak, Jonathan B. Overdevest, Zara Patel, Daniella K. Safatian, Rodney J. Schlosser, Brent Senior, Amanda L. Stapleton, Timothy L. Smith, Zachary M. Soler, Jeffrey D. Suh, Grant A. Turner, Marilene B. Wang, Milene T. Saavedra, Jennifer L. Taylor‐Cousar, Daniel M. Beswick   +34 more
wiley   +1 more source

Novel planning pipeline utilizing the Surgical Theater system for pediatric epilepsy surgery

Epilepsia Open, EarlyView.
Abstract Objective Advances in the analysis and collation of radiographic datasets have enhanced presurgical planning for various neurosurgical procedures, including clipping of cerebral aneurysms, surgical resection of tumors, and arteriovenous malformation management.
Lisa B. E. Shields, Hunain Abri, Cemal Karakas, Shannon D. Davis, Ian S. Mutchnick   +4 more
wiley   +1 more source

Human Capital Robotic Integration and Value Creation for Organizations

Journal of Organizational Behavior, EarlyView.
ABSTRACT Due to rapid advancements in artificial intelligence and machine learning, the research conversation has drifted from viewing robots as replacements for humans (i.e., the substitute view) to a view that considers the possible benefits of human–robot collaboration in the workplace (i.e., the complementary view).
Chou‐Yu Tsai, Jason D. Marshall, Rory Eckardt, Shelley D. Dionne, Malte F. Jung, YoYo Tsung‐Yu Hou, Biying Yang   +6 more
wiley   +1 more source

Management guidelines for disorders/different sex development (DSD)

Anales de Pediatría (English Edition), 2018
Disorders of sex development (DSD) include a wide range of anomalies among the chromosomal, gonadal, and phenotypic (genital) characteristics that define sexual differentiation.
Julio Guerrero-Fernández, Cristina Azcona San Julián, Jesús Barreiro Conde, José Antonio Bermúdez de la Vega, Atilano Carcavilla Urquí, Luis Antonio Castaño González, José María Martos Tello, Amaya Rodríguez Estévez, Diego Yeste Fernández, Leopoldo Martínez Martínez, María José Martínez-Urrutia, Cristina Mora Palma, Laura Audí Parera   +12 more
doaj   +1 more source

Cytogenomic Investigation of Syndromic Brazilian Patients with Differences of Sexual Development

Diagnostics, 2023
Background: Cytogenomic methods have gained space in the clinical investigation of patients with disorders/differences in sexual development (DSD). Here we evaluated the role of the SNP array in achieving a molecular diagnosis in Brazilian patients with ...
José Antonio Diniz Faria, Daniela R. Moraes, Leslie Domenici Kulikowski, Rafael Loch Batista, Nathalia Lisboa Gomes, Mirian Yumie Nishi, Evelin Zanardo, Carolina Kymie Vasques Nonaka, Bruno Solano de Freitas Souza, Berenice Bilharinho Mendonca, Sorahia Domenice   +10 more
doaj   +1 more source

Assessing Climate Change Impacts on Runoff Variability and Extremes in China Using High‐Resolution Simulations

International Journal of Climatology, EarlyView.
Future runoff in China shows strong regional and seasonal disparities, with the Southeast basin seeing the largest increase in annual runoff. Wetter summers and drier winters are expected in the south, whilst the northwest will face the opposite. Over 56% of regions are expected to experience more extreme high runoff, and over 40% face intensified low ...
Danyang Gao, Toby Richard Marthews, Guangtao Fu, Li Zhou, Fayyaz Ali Memon   +4 more
wiley   +1 more source