Results 51 to 60 of about 16,769 (199)

Temperature homeostasis disruption and hypothalamic alterations in experimental drug‐resistant epilepsy

Epilepsia, EarlyView.
Abstract Objective Elevated body temperature may increase seizure risk, yet the relationship between thermoregulation and seizures, as well as the underlying mechanisms, remains poorly understood. We investigated whether thermoregulatory control is altered in experimental temporal lobe epilepsy (TLE), as such impairment could reduce the ability of ...
Rossella Di Sapia, Akash Bera, Omar Mamad, James D. Mills, Benjamin Villasana‐Salazar, Giada Lavigna, Edoardo Micotti, Manuela Conticello, Asmin Alam, Roberto Chiesa, Francesca Pagani, Roberta Frapolli, Angelo M. Lavecchia, Christodoulos Xinaris, Eleonora Aronica, Andre Altmann, Teresa Ravizza, Sanjay M. Sisodiya, David C. Henshall, Annamaria Vezzani   +19 more
wiley   +1 more source

Thinking Outside the Rocks: Subsurface Water Storage, Topography, and Land Cover Are Key Modulators of Large‐Scale Riverine Dissolved Silicon Dynamics

Geophysical Research Letters
Riverine dissolved silicon (DSi) dynamics reflect integrated geologic, hydrologic, climatic, and ecological controls. We compiled annual DSi data for 337 rivers across four continents and trained interpretable machine‐learning models to predict ...
Sidney A. Bush, Keira Johnson, Kathi Jo Jankowski, Joanna C. Carey, Lienne R. Sethna, Nicholas J. Lyon, Pamela L. Sullivan   +6 more
doaj   +1 more source

Adeno‐associated virus‐mediated restoration of NaV1.1 in targeted brain regions ameliorates epilepsy in symptomatic Dravet syndrome mice

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of NaV1.1 voltage‐gated sodium channel. The disease manifests with febrile and spontaneous seizures, developmental delay, cognitive impairment, and increased risk of sudden ...
Martina Mainardi, Simone Brusco, Serena Gea Giannelli, Vania Broccoli, Gaia Colasante   +4 more
wiley   +1 more source

Exploring Liminal Spaces in Older Age: Navigating the Enduring State of Dual Sensory Impairment (DSI)

SAGE Open
Dual sensory impairment (DSI), a combination of vision and hearing loss, presents significant social and physical challenges to older adults and their social networks.
Moira E. Dunsmore, Julie Schneider, Heather McKenzie, James A. Gillespie   +3 more
doaj   +1 more source

The integrated benthic silicate flux in the Baltic Sea suggests a major land- or freshwater-derived reactive silicon source [PDF]

Biogeosciences
Coastal marine environments are hot spots in the global marine silicon (Si) cycle. Dissolved silicate (dSi) is an essential macronutrient for diatoms, which often dominate primary productivity in temporal coastal seas and constitute a key food source for
N. Ekeroth, N. Ekeroth, M. Kononets, S. Bonaglia, V. Brüchert, E. K. Robertson, A. Tengberg, A. Tengberg, P. O. J. Hall   +8 more
doaj   +1 more source

The Effort of Caring: The Caregivers’ Perspective of Dual Sensory Impairment

Frontiers in Education, 2020
AimTo explore the social experiences of Dual Sensory Impairment (DSI) for older Australian adults from the perspective of their family carers.BackgroundDSI in older adults is a chronic progressive disability with varying combined degrees of vision and ...
Moira E. Dunsmore, Moira E. Dunsmore, Moira E. Dunsmore, Julie Schneider, Heather McKenzie, James A. Gillespie, James A. Gillespie   +6 more
doaj   +1 more source

Directionality Scaling of Scalar and Vector Ground Motion Intensity Measures

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT The azimuthal directionality of earthquake ground‐motion intensity measures (IMs) is conventionally described by the ratios between the orientation‐independent maximum (RotD100) and median (RotD50) values over the horizontal plane. This study presents a refined characterization of the directionality of 31 IMs, including spectral accelerations (
Mao‐Xin Wang, Gang Wang
wiley   +1 more source

Diatoms modify the relationship between dissolved silicon and bicarbonate in the impounded rivers

Journal of Limnology, 2013
In order to investigate the relationship between dissolved silicon (DSi) and bicarbonate (HCO3–), we analysed water samples from the main Changjiang channel and its main tributaries in August 2006 and, during 2007-2009, the contrasting tributaries ...
Baoli Wang, Cong-Qiang Liu, Fushun Wang, Benjamin Chetelat, Stephen C. Maberly   +4 more
doaj   +1 more source

Development and Preliminary Validation of a Modified Thyroid Symptom Questionnaire (TSQ)

Head &Neck, EarlyView.
ABSTRACT Background This study aimed to modify and validate the Thyroidectomy Voice and Symptom Questionnaire (TVSQ) to serve as a symptom screening tool in benign thyroid disease. Methods A 32‐item modified TVSQ was developed and administered alongside a symptom checklist to outpatients; controls were recruited to determine discriminative validity ...
Vikash Yogaraj, Debra Phyland, Catherine Sinclair   +2 more
wiley   +1 more source

The association between dual sensory impairment and social participation among older adults in China: a moderated mediation model of activities of daily living and depressive symptoms

BMC Geriatrics
Background While dual sensory impairment (DSI) is known to reduce social participation (SP) in older adults, the underlying mechanisms remain unclear. Therefore, the aim of this study was to ascertain: (1) whether ADL mediates the relationship between ...
Lunxin Liu, Zhenglin Cao, Qingshan MA, Zhiliu Liao   +3 more
doaj   +1 more source