Results 91 to 100 of about 258,335 (279)

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy

Advanced Science, EarlyView.
This study constructed the W1/O/W2 emulsion–based targeted therapy delivery system for ulcerative colitis (UC) utilizing LCC as surfactant for the first time. This multifunctional emulsion offered certain therapeutic advantages for UC, including targeted colonic delivery of active compounds, synergistic modulation of gut microbiota through combined ...
Qian Wu, Xingyu Zhang, Jingjia Zhang, Gaohui Huang, Chen Zhou, Chunlin Li, Xiaojun Huang, Jianbo Xiao, Nianjie Feng, Yuanbin She   +9 more
wiley   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Programmable Semi‐Interpenetrating Living Materials With Robust Stability for Versatile Bioremediation and Biotherapeutics

Advanced Science, EarlyView.
A semi‐interpenetrating engineered living material (sIHSELM), fabricated via thermosensitive hydroxybutyl chitosan and covalent protein self‐assembly, demonstrates exceptional mechanical properties and environmental stability. Shielding bacteria from harsh conditions, sIHSELM exhibits remarkable efficacy in ulcerative colitis treatment and pollutants ...
Zixian Bao, Shengfeng Yang, Dandan Hu, Jiezheng Liu, Bo Jiang, Xinyue Sui, Qingsheng Qi, Lai Li, Guang Zhao   +8 more
wiley   +1 more source

Extended Fused Carbazole‐BODIPY, High Brightness NIR Organic Dyes

Angewandte Chemie, EarlyView.
Highly fused boron‐dipyrromethene (BODIPY) with a strong donor group has been synthesized, and their photophysical behaviors fully characterized. They exhibit outstanding brightness for fluorophores emitting in the NIR region. Water‐soluble nanoparticles filled with one of these dyes demonstrate high efficiency as the NIR II visualization agent ...
Fabien Ceugniet, Valentin Ott, Pascal Retailleau, Yann Bretonniere, Olivier Maury, Manon H. E. Bousquet, Lucie Sancey, Nicolas Leclerc, Denis Jacquemin, Gilles Ulrich   +9 more
wiley   +2 more sources

The role of soil and forest characteristics in planning hydraulic-forestry and bioengineering works: Lessons from the Italian experience

EQA
Soil plays a crucial role in hydraulic-forestry and bioengineering works, influencing the design, construction, and implementation of measures aimed at mitigating land degradation and promoting environmental restoration.
Edoardo A.C. Costantini, Federico Preti
doaj   +1 more source

Higher education decision making and decision support systems [PDF]

The authors illustrate several issues in decision support and decision support systems (DSS), state of the art research in these fields, and also their own studies in designing a higher education DSS.
Bresfelean, Vasile Paul, Ghisoiu, Nicolae   +1 more
core   +1 more source

Economic and Environmental Tradeoffs in Cultivating Short Food Supply Chains With Urban Indoor Agriculture

Agribusiness, EarlyView.
ABSTRACT This study advances the literature on sustainable urban agriculture and alternative sustainable food production systems, which have gained momentum due to the need to strengthen regional food supply chains and meet the growing urban demand for fresh food. Indoor agriculture (IA) holds promise for year‐round cultivation of fresh produce even in
Joseph Seong, H. Christopher Peterson, Simone Valle de Souza   +2 more
wiley   +1 more source

Sustainable North-South Africa Collaboration for Disaster and Crisis Management: A Strategic Capacity Development Framework using Open Science, Artificial Intelligence and Geoinformatics

Data Science Journal
Background: This paper explores strategies to enhance North-South collaboration to foster multi- and trans-disciplinary research in disaster risk reduction (DRR) and crisis management, emphasizing the role of open science, Artificial Intelligence (AI ...
Rania Elsayed Ibrahim, Tshiamo Motshegwa, Djillali Benouar, Mohamed Khodja, Hamed Ead, Lili Zhang, Francais Crawley, Nokuthula P. Mchunu, Sepo Hachigonta, Simon Hodson, Vanessa Mcbride, Teketel Yohannes   +11 more
doaj   +1 more source

SISTEM PENDUKUNG KEPUTUSAN PENERIMAAN ASISTEN LABORATORIUM MENGGUNAKAN METODE MULTI FACTOR EVALUATION PROCESS (MFEP)

Jurnal Riset Informatika, 2019
Asisten LAB ICT merupakan mahasiswa Fakultas Teknologi Informasi dan Fakultas Ekonomi dan Bisnis yang aktif. Asisten Laboratorium mempunyai tugas mendampingi dosen pada saat dosen mengajar praktikum di LAB ICT, dan harus memahami materi praktikum dosen ...
Painem Painem, Hari Soetanto
doaj   +1 more source