Results 171 to 180 of about 318,315 (344)

Predominance of In‐Field Recurrence After Radiotherapy for Sinonasal Cancer: A Single‐Center Retrospective Study

Head &Neck, EarlyView.
ABSTRACT Background Sinonasal malignancies (SNM) are rare, heterogeneous tumors with poor prognosis. There is an unmet need to improve treatment outcomes. Despite advances in imaging and molecular classification, optimal curative radiotherapy (RT) strategies remain undefined.
M. de Ridder, L. J. van de Velde, T. de Bie, R. van Noortwijk, C. P. J. Raaijmakers, E. H. Voormolen, W. W. Braunius, R. de Bree, G. E. Breimer, L. A. Devriese, E. J. Smid, J. A. Rijken   +11 more
wiley   +1 more source

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

Interdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang, Jiaqi Zhou, Hang Qiao, Yifan Jia, Ling Ye, Zeli Li, Jiahe Ouyang, Haoxian Zhou, Kangxin Zeng, Xuemeng Wang, Yixian Wang, Yang Zhang, Yupeng Zhang, Yizhou Cai, Yutao Hu, Minzhe Zhang, Wenwei Xu, Zhenzhen Wu, Xiaofang Qiu, Li Lin   +19 more
wiley   +1 more source

Evolutifon of decision support system architectures: applications to land planning and management in Cuba

Journal of Computer Science and Technology, 2003
The main objective of this paper centers on reviewing the evolution of Decision Support System´s (DSS) architectures, particularly as they apply to natural resources.
Saddys Segrera, Raúl Ponce-Hernandez, J. Arcia   +2 more
doaj  

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

Towards Water, Food and Energy Security: The Global Challenges and Possible Solutions for a Holistic Vision of Sustainability

Irrigation and Drainage, EarlyView.
ABSTRACT This invited paper gives an overview of the challenges the world is facing and offers a possible solution for water and food security within the holistic integrated concept of the water–energy–food (WEF) nexus. The paper summarizes the experience the author gained through working on various research projects at national and international ...
Ragab Ragab
wiley   +1 more source

The Diabetes Staging System (DSS): A Pilot Study Assessing Feasibility, Provider Engagement and Implementation Challenges of a Novel Staging System for Type 2 Diabetes. [PDF]

Diabetes Metab Syndr Obes
Dar MS, Zhang J, Ashline A, Kota S, Woolson S, Majette NT, Bosworth HB.   +6 more
europepmc   +1 more source

‘Pre‐Technologies’ and the Lifeworld: Assistive Technologies as ‘Pre‐Technologies’ for Self‐Formation as Freedom

Journal of Applied Philosophy, EarlyView.
ABSTRACT This article identifies assistive technologies (ATs) as ‘pre‐technologies’ mediating access to other technologies for disabled subjects (DSs). The motivation is to show that without ATs, DSs cannot be said to have the same level of access to freedom and self‐forming activities as able‐bodied subjects.
Sarel Marais
wiley   +1 more source

Monoclonal antibody inhibition of PAR2 reduces phenotype severity and pain in murine inflammatory bowel disease. [PDF]

Pain Rep
Ritoux A, Grundy LJ, Manjappa P, Paine LW, Neisen J, Linley JE, Smith ESJ.   +6 more
europepmc   +1 more source

Relationships between periodontitis, tooth loss, and metabolic syndrome indicators

Journal of Periodontology, EarlyView.
Abstract Background This study investigates how poor oral health impacts metabolic alterations, specifically evaluating the effects of periodontitis and tooth loss, either individually or in combination, on the number of metabolic syndrome (MetS) indicators.
Verbênia Silva Conceição, Isaac Suzart Gomes‐Filho, Simone Seixas da Cruz, Michelle Santana Xavier Ramos, Ana Claudia Morais Godoy Figueiredo, Soraya Castro Trindade, Daiane Silva Sampaio, Maria Clara Azevedo Moreira, Eneida de Moraes Marcílio Cerqueira, Josicélia Estrela Tuy Batista, Alexandre Marcelo Hintz, Gregory John Seymour, Frank Andrew Scannapieco, Peter Michael Loomer, Johelle de Santana Passos‐Soares   +14 more
wiley   +1 more source

The JNK2-microbiome axis modulates gut barrier integrity through microbial acetate. [PDF]

Gut Microbes
Chongtham C, Biswas T, Kumari N, Kar R, Jyotsna, S J, Pant A, S Patil V, Arimbasseri GA.   +8 more
europepmc   +1 more source