Results 41 to 50 of about 7,514 (191)

Jiang Zhi Granule protects immunological barrier of intestinal mucosa in rats with non-alcoholic steatohepatitis

Pharmaceutical Biology, 2021
Context Jiang Zhi Granule (JZG) is known to improve hepatic function, reduce liver fat deposition and inflammation in non-alcoholic fatty liver disease (NAFLD). Objective To determine the protective mechanism of JZG on immunological barrier of intestinal
Xiao Yu, Haiyan Zhang, Jielu Pan, Lu Zou, Ling Tang, Hongyu Miao, Peiyong Zheng, Lianjun Xing   +7 more
doaj   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Resolvin D5 Inhibits CXCL8 Expression in Colonic Epithelial Cells Through Activating GPR101 to Impede Neutrophil Recruitment and Consequently Alleviate Ulcerative Colitis

Advanced Science, EarlyView.
RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo, Yilei Guo, Yanrong Zhu, Ke Yan, Yulai Fang, Jiafeng Zhang, Yue He, Zhifeng Wei, Yufeng Xia, Yue Dai   +9 more
wiley   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Sicurezza a scala territoriale: il ruolo degli strumenti di supporto alle decisioni

GEOmedia, 2019
The problems to be overcome to deal with emergency situations in case of natural disasters can be many and, especially in recent years, require specific skills in various areas.
Stefano Marsella, Marcello Marzoli
doaj   +3 more sources

A organização e a dinâmica participativa dos segmentos sociais nas Conferências Municipais de Saúde (Organization and active participation of social segments in Municipal Health Conferences) Doi: 10.5212/Emancipacao.v.12i1.0008

Emancipação, 2012
Este texto descreve e analisa o processo organizativo e a dinâmica participativa dos diferentes segmentos que integraram as Conferências Municipais de Saúde, realizadas nos anos de 2003 e 2007 em nove municípios de Santa Catarina.
Tânia Regina Krüger, Ana Paula Lemke, Daiana Nardino Dias, Marta de Lourdes de Almeida Nunes, Jaqueline da Rosa Meggiato, Solange Janete Finger, Dalila Maria Pedrini   +6 more
doaj  

Decision Support System for Outstanding Students’ Selection Using TOPSIS

Jurnal Riset Informatika
In the school environment, determining outstanding students holds significant importance. High academic achievement among students and a low failure rate reflect the overall quality of education.
Irma Suryani, Asrul Sani, Agus Budiyantara, Nur Nawaningtyas Pusparini   +3 more
doaj   +1 more source

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source

WebGIS-based decision support system for soil erosion assessment in Legedadi watershed, Oromia Region, Ethiopia

Geology, Ecology, and Landscapes, 2021
Soil erosion is one of the major environmental issues in Ethiopia. In highlands, though the topography is rugged; settlements have increased in recent years even if cultivation is generally practiced on steep landforms.
Tsedale Gebreegziabher, Karuturi Venkata Suryabhagavan, Tarun Kumar Raghuvanshi   +2 more
doaj   +1 more source

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source