Results 91 to 100 of about 26,978 (258)
ABSTRACT Objectives The “valley of death” between research and practice remains a major challenge. The five‐stage Translational Research framework (TR1‐TR5) provides a pathway, moving evidence into real‐world impact. Traditionally, Randomised Controlled Trials (RCTs) dominate TR stages, yet they are often impractical in public health.
An T. M. Dao +4 more
wiley +1 more source
Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney +10 more
wiley +1 more source
How to Demonstrate Trustworthy Use of AI in Public Services: A Case Study
ABSTRACT Government leaders across the globe are grappling with how to harness and integrate artificial intelligence (AI) to enhance public service delivery and efficiency. Yet, a key challenge faced is how to build and maintain the trust of stakeholders. Trust is critical for the acceptance and sustained adoption of AI technologies, as well as to gain
Natalie Smith +5 more
wiley +1 more source
ABSTRACT Most organisations are confronting a dilemma: the need to embark on digital transformation to be competitive and sustainable versus the inherently high costs and extremely high risks involved. Lack of executive support has long been identified as a leading cause of project failure, including digital transformation projects.
Natalie Smith, Andrew Burton‐Jones
wiley +1 more source
Accurate calculation of drug-target affinity (DTA) is crucial for various applications in the pharmaceutical industry, including drug screening, design, and repurposing.
Xin Zeng +4 more
doaj +1 more source
Climate‐Neutrality Transition and Banks' Loan Pricing
Abstract In this paper, we propose a novel methodology to quantify firms' climate‐change transition risk (CCTR) and its implications for credit markets. We utilize the regulatory framework of the European Green Deal's 2050 carbon neutrality roadmap, focusing on large Eurozone firms and their banking relationships.
Evangelos Salachas +2 more
wiley +1 more source
F-5M DTA PROGRAM. doi: 10.5028/jatm.2009.0101113120
The Brazilian F-5 was submitted to avionics and weapons upgrade. This “new” aircraft has proven to be heavier and more capable. A comprehensive damage tolerance analysis is being performed to evaluate how the new mission profiles and weight distribution ...
Daniel Ferreira V. Mattos +2 more
doaj
Background Staphylococcus aureus (S. aureus) is one of the most widespread bacterial pathogens in animals and humans, and its role as an important causative agent of food poisoning is well-documented.
Namwin Siourimè Somda +8 more
doaj +1 more source
Mapping the murine TMJ glenoid fossa over development, homeostasis and in response to disease
The fibrocartilage of the murine glenoid fossa and condyle of the temporomandibular joint are shown to form at distinct times with distinct molecular identities. Changes in the condyle during disease lead to remodelling of the fossa to maintain joint alignment.
Ticha Tuwatnawanit +4 more
wiley +1 more source
Demographic Dynamics and International Trade: Stylized Facts and Theoretical Insights
ABSTRACT Demographic change within a country has economic repercussions for other countries through international transactions. Ongoing shifts in population size and age structure across countries have important implications for international trade, operating through changes in market size, consumption preferences, and labor supply.
Kumuthini Sivathas
wiley +1 more source

