Results 121 to 130 of about 74,950 (296)

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

Sensitizer‐Induced Basophils Accelerate Skin Re‐Epithelialization via IL‐4/IL‐13‐Mediated Macrophage Polarization

Allergy, EarlyView.
Oxazolone exposure drives rapid basophil recruitment to wounded skin, accelerating re‐epithelialization, angiogenesis, and tissue regeneration. Basophils are the dominant early source of IL‐4 and IL‐13 in the wound microenvironment. Basophil‐derived IL‐4/IL‐13 promote macrophage polarization toward a pro‐repair M2 phenotype, enabling efficient wound ...
Yufei Zhang, Xueting Peng, Kaixuan Ren, Shiran Kang, Zihan Xue, Yazhuo Li, Zhu Yan, Rongfang Feng, Min Gao, Qin Chen, Xiaoying Ning, Fan Bai, Liesu Meng, Yumin Xia, Yale Liu   +14 more
wiley   +1 more source

A Review of the Application of Decision Tree Analysis and Artificial Neural Networks in Project Management

Jurnal Teknik Industri: Jurnal Hasil Penelitian dan Karya Ilmiah dalam Bidang Teknik Industri
The advancement of computing and communication technologies has fueled the growth of Information Technology (IT), with Artificial Intelligence (AI) emerging as a transformative force in modernizing project management practices.
Olusina Temidayo Akinyokun, Onifade. Morakinyo Kehinde, Adegoke Michael Abejide   +2 more
doaj   +1 more source

The Testicular Cancer Consortium (TECAC): Filling Knowledge Gaps in the Genetic Etiology of Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The Testicular Cancer Consortium (TECAC) was established in 2012 and is comprised of researchers from over 25 centers in Europe and North America. TECAC's overarching goal is to investigate the genetic susceptibility of testicular germ cell tumors (TGCT) to better understand their biology, impact prevention strategies, and inform ...
Peter A. Kanetsky, Kristian Almstrup, Svetlana Cherlin, Victoria K. Cortessis, Alberto Ferlin, Jourik A. Gietema, Anna González‐Neira, Tom Grotmol, Robert J. Hamilton, Trine B. Haugen, Lambertus A. Kiemeney, Jung Kim, Csilla Krausz, Davor Lessel, Ragnhild A. Lothe, Kevin T. Nead, Jérémie Nsengimana, Jenny N. Poynter, Ewa Rajpert‐DeMeyts, Lorenzo Richiardi, Stephen M. Schwartz, Rolf I. Skotheim, Douglas R. Stewart, Clare Turnbull, Fredrik Wiklund, Tongzhang Zheng, Katherine L. Nathanson, Katherine A. McGlynn, for the Testicular Cancer Consortium   +28 more
wiley   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Diagnostic Accuracy of Deep Learning Models in Detecting Peri‐Implant Marginal Bone Loss: A Systematic Review and Meta‐Analysis

Clinical Oral Implants Research, EarlyView.
ABSTRACT Background Peri‐implantitis is a common implant complication requiring early detection to prevent bone loss and implant failure. Deep learning models show promise for enhancing radiographic diagnosis. Objectives This review systematically evaluated the diagnostic performance of deep learning models in detecting peri‐implant marginal bone loss ...
Momen A. Atieh, Maanas Shah, Abeer Hakam, Fawaghi AlAli, Samhar AlSayed, Andrew Tawse‐Smith, Nabeel H. M. Alsabeeha   +6 more
wiley   +1 more source

Genome and transcriptome‐based identification and expression profiling of chemosensory gene families across developmental stages and tissues in Sirex noctilio (Hymenoptera: Siricidae)

Insect Molecular Biology, EarlyView.
The first draft genome of Sirex noctilio was produced. Fifteen S. noctilio transcriptomes were sequenced to study chemosensory gene expression patterns. SnocOR16 and SnocSNMP1 displayed tissue‐ and sex‐specific expression patterns. Abstract The Sirex woodwasp (Sirex noctilio; Hymenoptera: Siricidae) is among the most destructive invasive pests ...
Alisa Postma, Leandri Klynsmith, Tuan A. Duong, Jeremy Dean Allison, Werner Smidt, Robert M. Waterhouse, Peter Lesny, Jan Philip Oeyen, Malte Petersen, Sebastian Martin, Shanlin Liu, Xin Zhou, Tanja Ziesmann, Alexander Donath, Christoph Mayer, Bernhard Misof, Oliver Niehuis, Ralph S. Peters, Lars Podsiadlowski, Martin P. A. Coetzee, Fourie Joubert, Bernard Slippers   +21 more
wiley   +1 more source

Climate‐Neutrality Transition and Banks' Loan Pricing

Journal of Financial Research, EarlyView.
Abstract In this paper, we propose a novel methodology to quantify firms' climate‐change transition risk (CCTR) and its implications for credit markets. We utilize the regulatory framework of the European Green Deal's 2050 carbon neutrality roadmap, focusing on large Eurozone firms and their banking relationships.
Evangelos Salachas, Maria‐Eleni K. Agoraki, Georgios P. Kouretas   +2 more
wiley   +1 more source

Dehydration kinetics investigation of refractory concrete during sintering using DTA method

, 2011
The base mix refractory concrete is corundum based, containing corundum as refractory aggregate and CAC as hydraulic binder, with spinel as an additive. The authors investigated the dehydration reactions which occur from the moment when water is added (at the beginning of components mixing), to the moment when installed refractory concrete lining is ...
Obradović, Nina, Terzić, Anja, Pavlović, Ljubica, Filipović, Suzana, Pavlović, Vladimir B.   +4 more
openaire   +1 more source