Results 131 to 140 of about 20,471 (284)
Reductive Methylation: An Alternative to Lysine → Arginine Mutagenesis
Journal of Peptide Science, Volume 32, Issue 7, July 2026.Replacing lysine with arginine, the standard genetic approach to eliminate amine reactivity, alters physicochemical properties and leaves the N terminus unprotected. Here, reductive methylation is characterized as a conservative chemical alternative. Complete dimethylation of human ribonucleases preserves thermostability, protein–protein interaction ...
Oscar J. Molina +4 more
wiley +1 more source
Free Vibration Analysis of Nanoplates using Differential Transformation Method [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2017 In this paper, a free vibration of nano-plates is investigated considering the small scale parameter. The used rectangular nano plate is thin and under different boundary conditions.
Sayed Hassan Nourbakhsh +2 more
doaj
, 2023 O vídeo apresenta um diálogo multidisciplinar sobre o Distúrbio Miofuncional em DTM. Participam do diálogo cirurgiãs-dentistas, fonoaudiólogas e uma fisioterapeuta. O objetivo é capacitar o acadêmico e o profissional de odontologia a realizar um trabalho
Seitenfus, Daniela Disconzi +5 more
core
Fundamental &Clinical Pharmacology, Volume 40, Issue 4, July 2026.ABSTRACT The effects of obesity on the vasculature and perivascular adipose tissue (PVAT) function vary according to the vascular territory. Nebivolol is a third‐generation β‐blocker that exerts vasculoprotective effects in obesity. The thoracic and abdominal aorta show different responses under physiological conditions, and their PVATs have a ...
Thales M. H. Dourado +5 more
wiley +1 more source
DTM — Core Kosmiko presents the minimal structural framework required for the stabilization of form. It defines the vertical axis (Nadir–Zenith), the horizontal torsional axis (G–A–Q), the perceptual projection (RGB), the sensorial anchoring system (5K), the vectorial chain (H–REK–ρ), the harmonic rhythm (432/8), and the dynamic operator ( ihde ...
openaire +1 more source
, 2008 INTRODUCTION: the involvement of TMJ through degenerative changes and displacements of the articular disc proved to be an important risk factor when identifying individuals with vertical facial growth patterns.
Tesch,Ricardo de Souza +5 more
core +1 more source
Review of Policy Research, Volume 43, Issue 4, July 2026.ABSTRACT The accelerated digitalisation of society has amplified cybersecurity threats and revealed their cross‐sectoral nature. Yet, the policy instruments used to address these challenges remain insufficiently examined. This study conducts a scoping review of 980 academic articles (2007–2024) and applies Hood's NATO framework (Nodality, Authority ...
Benedetta Cotta, Maria Stella Righettini
wiley +1 more source
ChemMedChem, Volume 21, Issue 11, 15 June 2026.We developed new derivatives of the cancer drug ponatinib, significantly reducing and altering its spectrum of target kinases. Compound 5 retained the efficacy in inhibiting the colony formation of MDA‐MB‐231 cells and acted primarily on B‐Raf and Flt‐1 as its main targets in a kinase panel.
Tobias Betzholz +7 more
wiley +1 more source
Comparing rotational-field-dTMS to unidirectional-dTMS in healthy volunteers
Brain Stimulation, 2019 Y. Roth +8 more
openaire +1 more source
Design and Synthesis of Pyrimidino[4,5‐d]Pyrimidine‐Based Compounds as Potent B‐RAF V600E Inhibitors
ChemMedChem, Volume 21, Issue 11, 15 June 2026.Novel pyrimido[4,5‐d]pyrimidine‐based inhibitors selectively target B‐RAF V600E with nanomolar affinity and adopt distinct type‐II binding modes. Complementary cellular profiling reveals highly active analogs, underscoring the versatility of this chemotype and establishing it as a promising scaffold for the development of next‐generation kinase ...
Eleftheria A. Georgiou +10 more
wiley +1 more source