Results 41 to 50 of about 9,219 (249)

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Concepts of 3D terrain modeling and geomorphometric analysis in mining [PDF]

Mining and Metallurgy Engineering Bor, 2016
This paper describes the concepts of 3D terrain models and their application in mining. The methods of terrain (relief) by spots elevation and contour lines are commonly applied on geodetic plans and topographic maps.
Petrović Vladimir M., Zlatanović Dragan, Borisov Mirko, Đurđevac-Ignjatović Lidija   +3 more
doaj   +1 more source

Prospecting of Architectural Features Using LiDAR‐UAV Technology, Deep Neural Networks and Visualization Techniques: A Case Study in Kuélap and Cambolín (NW Peru)

Archaeological Prospection, EarlyView.
ABSTRACT High‐resolution and accurate synoptic images of terrestrial topography, even in densely forested areas, have proven valuable for archaeology by enabling the identification and characterization of relief patterns associated with ancient human activities. This study presents a novel approach that integrates digital terrain models (DTMs) obtained
Jhon A. Zabaleta‐Santisteban, Rolando Salas López, Angel J. Medina‐Medina, Katerin M. Tuesta‐Trauco, Abner S. Rivera‐Fernandez, Nerci M. Noriega‐Salazar, José A. Sánchez‐Vega, Teodoro B. Silva‐Melendez, Marlen A. Grandez‐Alberca, Jhonsy O. Silva‐López, Nilton B. Rojas‐Briceño, Manuel Oliva‐Cruz, Alexander Cotrina‐Sanchez, Elgar Barboza   +13 more
wiley   +1 more source

Comparison of regional elevation heights in the Aguascalientes basin using DGPS technique with INEGI’s digital terrain model

Geofísica Internacional, 2010
Las alturas de ochenta y un puntos fueron medidas usando receptores DGPS en bancos de nivel de INEGI y una estación geodética. Cincuenta y ocho puntos se midieron utilizando dos receptores y veintitrés puntos utilizando tres receptores.
M. Ortiz, J. A. Reyna, M. Balcazar, A. Hernández Espriu, L. E. Marín   +4 more
doaj   +1 more source

Integrating Remote Sensing, Archaeological Survey and Geophysical Prospections for the Enhancement of Roman Doclea, Montenegro

Archaeological Prospection, EarlyView.
ABSTRACT The Roman city of Doclea is a key archaeological site of Montenegro, valued for its impressive remains and its role in the nation's cultural identity within European and the Mediterranean history. Doclea was the second‐largest city in the province of Roman Dalmatia, a municipium created in the first century ad and named after the Illyrian ...
Tatjana Koprivica, Lucia Alberti, Marilena Cozzolino, Bruna Di Palma, Vincenzo Gentile, Pasquale Merola   +5 more
wiley   +1 more source

Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches

Chemistry – A European Journal, EarlyView.
We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal, Hugo Laigle, Maxime Mansy, Sébastien Ulrich, Mathieu Surin   +4 more
wiley   +1 more source

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

Chemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup, Peter Reinholdt, Kasper Munch Beck, Michael Petersen, Jean‐Louis Mergny, Poul Nielsen   +5 more
wiley   +1 more source

Detection of former landfills in gravel plain using geomorphometric analysis and High-Resolution LiDAR DTM

Acta Geographica Slovenica, 2014
The article represents the application of geomorphologic approach to discover the potential areas of buried waste in agricultural landscape of Ljubljana gravel plain.
Mateja Breg Valjavec
doaj   +1 more source