Results 41 to 50 of about 14,014 (189)

Impacts of horizontal mergers on dual-channel supply chain

Journal of Industrial & Management Optimization, 2022
<p style='text-indent:20px;'>This paper investigates the impacts of horizontal mergers on a dual-channel supply chain given the rapid development of e-commerce. Three types of horizontal mergers are considered in a dual-channel supply chain consisting of three firm types: suppliers, single-channel retailer, and dual-channel retailer. A comparison
Zhao, Xi, Niu, Teng
openaire   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Price and Service Competition of Dual-Channel Supply Chain with Consumer Returns

Discrete Dynamics in Nature and Society, 2014
Products returned by consumers are common in the retail industry and result in additional costs to both the manufacturer and the retailer. This paper proposes dual-channel supply chain models involving consumer returns policies.
Lili Ren, Yong He, Houfei Song
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Self-Built or Third-Party Blockchain Traceability Strategy in a Dual-Channel Supply Chain Considering Consumers’ Traceability Awareness

Mathematics, 2023
Blockchain is widely used in the manufacturing industry. This paper establishes a dual-channel supply chain composed of a manufacturer and an e-retailer. A monopoly manufacturer conducts indirect online selling through retailers as well as direct offline
Yuling Sun, Xiaomei Song, Xiang Fang, Jian Guo   +3 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Pricing strategies in a dual-channel green supply chain with cannibalization and risk aversion

Operations Research Perspectives, 2019
This paper investigates a dual-channel supply chain in which a single manufacturer offers the standard product through a direct online channel and an inaugural green product through a traditional physical store (regular) channel. The manufacturer invests
Syed Asif Raza, Srikrishna Madhumohan Govindaluri   +1 more
doaj   +1 more source

Robust Control Strategy for Dual-Channel Supply Chain With Free Riding Behavior and Cross-Channel Return

IEEE Access, 2023
In order to obtain customer satisfaction and promote the overall revenue of the supply chain system, offline purchase and online return strategy, called a new kind of cross channel return strategy (hereinafter referred to as “cross channel return&#
Yuxiang Xia, Chengcheng Li
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source