Results 71 to 80 of about 535,352 (239)

Long-Time Coherent Integration for the Spatial-Based Bistatic Radar Based on Dual-Scale Decomposition and Conditioned CPF

Remote Sensing
This paper addresses the problem of weak maneuvering target detection in the space-based bistatic radar system through long-time coherent integration (LTCI).
Suqi Li, Yihan Wang, Yanfeng Liang, Bailu Wang   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Decompose-Disentangle-Decode Time Series Forecasting (D3TSF): dual-scale time series forecasting via seasonality of patch-wise state space and sparse trend learning

Journal of King Saud University: Computer and Information Sciences
Long-term time series forecasting remains a challenging task due to the complex entanglement of temporal patterns and the inherent limitations of traditional attention mechanisms in capturing long-range dependencies efficiently.
Shenglin Liu
doaj   +1 more source

Miniature Multi-Target Tracking in Sonar Images Using Dual Trajectory Storage Method

Journal of Marine Science and Engineering
To address the conflict between trajectory fragmentation and the trade-off between association efficiency and data integrity in underwater micro-scale multi-target sonar motion detection and tracking in video sequences, a multi-target motion detection ...
Zhen Huang, Peizhen Zhang, Rui Wang, Xiaoyan Xian, Qi Wang, Jiayu Hu, Qinyu Wu   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Comparison of Short-Term efficacy between medial and lateral dual incision approach and medial dual incision approach for endoscopic spur resection combined with plantar fascia release in the treatment of heel pain syndrome

BMC Surgery
Background This study employed a retrospective analysis to compare the short-term efficacy of the medial and lateral dual incision approach versus the medial dual incision approach for endoscopic spur resection combined with plantar fascia release in the
Xuehai Dong, Feng Wan, Jingjing Zhang, Can Zhuo, Naxin Zhou   +4 more
doaj   +1 more source

The Impact of Dual-Career Support Systems on Perceived Barriers Among European Student-Athletes with Disabilities

Education Sciences
The aim of this study was to compare the socio-demographic, sporting characteristics and perceptions of student-athletes with disabilities of perceived barriers according to the state system of dual career support. Two hundred and twelve student-athletes
Alejandro Leiva-Arcas, Raquel Vaquero-Cristóbal, Lourdes Meroño, María José Maciá-Andreu, Juan Alfonso García-Roca, Lucía Abenza-Cano, Antonino Manuel Almeida-Pereira, Laura Capranica, Tom Comyns, Aura Bota, Amaia Ramírez-Muñoz, Luis Maicas-Pérez, Emanuele Isidori, Antonio Sánchez-Pato   +13 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source