Results 161 to 170 of about 1,805,046 (316)

A solid dual-salt plastic crystal electrolyte enabling rapid ion transfer and stable interphases for high-performance solid-state sodium ion batteries. [PDF]

Chem Sci
Jiang Y, Wang R, Xiong P, Liu Y, Li H, Zhang L, You Y, Zhang C.   +7 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Impact of dual-tasking and balance confidence on turns and transitions: a cross-sectional study in Parkinson's disease. [PDF]

Sci Rep
Johansson H, Löfgren N, Porciuncula F, Leavy B.   +3 more
europepmc   +1 more source

Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors

, 2016
Holger Kühne, U. Obst-Sander, Bernd Kuhn, Aurelia Conte, Simona Ceccarelli, Werner Neidhart, M.G. Rudolph, Giorgio Ottaviani, Rodolfo Gasser, Sung‐Sau So, Shirley Xin Li, Xiaolei Zhang, Lin Gao, Michael C. Myers   +13 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A Novel Dual-Task Paradigm for Return-to-Sport Screening After ACL Injury: A Pilot Study. [PDF]

Transl Sports Med
Lövgren A, Strong A, Boraxbekk CJ, Markström JL.   +3 more
europepmc   +1 more source

Examining the concurrent validity of markerless motion capture in dual-athlete team sports movements

Alexander Oonk, Matthias Kempe, Koen Lemmink, T J W Buurke   +3 more
openalex   +1 more source

In‐Hospital Outcomes of Dual Loading Antiplatelet Therapy in Patients 75 Years and Older With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: Findings From the CCC‐ACS (Improving Care for Cardiovascular Disease in China‐Acute Coronary Syndrome) Project

, 2018
Guanqi Zhao, Mengge Zhou, Changsheng Ma, Yong Huo, Sidney C. Smith, Gregg C. Fonarow, Junbo Ge, Yaling Han, Jing Liu, Yongchen Hao, Jun Liu, Xiao Wang, Kathryn A. Taubert, Louise Morgan, Dong Zhao, Shaoping Nie, the CCC‐ACS Investigators   +16 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source