Results 161 to 170 of about 2,778,255 (309)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Tobacco product cessation and prenatal care utilization: A Pregnancy Risk Assessment Monitoring System phase 8 study of conventional cigarette, e-cigarette, and dual-use associated behaviors. [PDF]

PLoS One
Shenoy RD, Weitzman M, Acuña JM.
europepmc   +1 more source

The dual process model of coping with bereavement: rationale and description.

Death Studies, 1999
M. Stroebe, H. Schut
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Alcohol consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): understanding the gut-liver crosstalk for clinical translation. [PDF]

Gut Microbes
Benedé-Ubieto R, Estévez-Vázquez O, Acar R, Leal-Lassalle H, Gutierrez AH, Redondo-Urzainqui A, Iborra S, Odintsova VE, Tyakht A, Herranz JM, Firat Z, Basol M, Korkmaz B, Sanz-García C, Juanola O, Caparrós E, Francés R, Ciudin A, Pericàs JM, Gómez-Santos B, Aspichueta P, Treichel N, Clavel T, Reißing J, Bruns T, Bartneck M, Mazariegos MS, Wolters JC, Jorquera G, Liedtke C, Vaquero J, Bañares R, Cakan-Akdogan G, Ávila MA, Konu O, Cubero FJ, Nevzorova YA.   +36 more
europepmc   +1 more source

Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation

New England Journal of Medicine, 2017
C. Cannon, Deepak L. Bhatt, J. Oldgren, G. Lip, S. Ellis, Takeshi Kimura, M. Maeng, B. Merkely, U. Zeymer, S. Gropper, M. Nordaby, E. Kleine, Ruth Harper, Jenny Manassie, J. Januzzi, J. T. ten Berg, G. Steg, S. Hohnloser   +17 more
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

All-solution-processed scalable and wearable organic thermoelectrics by structurally mimicking transverse thermoelectric effects. [PDF]

Sci Adv
Park J, Kim SH, Song JH, Jeong J, Kwak J.   +4 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Beyond the monorail perspective: constructing a dual-role engagement framework in peer feedback for second language oral communication. [PDF]

Front Psychol
He W, Jin X.
europepmc   +1 more source