Results 161 to 170 of about 2,398,337 (305)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Gating Modes in Ion Mobility-Mass Spectrometry: Principles, Advances, and Coupling With Mass Analyzers. [PDF]

Rapid Commun Mass Spectrom
Li T, Xiong S, Jiang T, Xu W.
europepmc   +1 more source

Dual Track Liberalization: With and Without Losers [PDF]

Dual track liberalization, relying upon the continued enforcement of existing contracts and the simultaneous creation of a free market sector, represents a powerful mechanism in economic reform.
Jiahua Che, Giovanni Facchini
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Dual-Task Performance as a Potential Digital Biomarker of Aging: Age-Stratified Reference Patterns Across the Adult Lifespan. [PDF]

J Clin Med
Murie-Fernández M, Larrinaga NM, Brito MC, Román CB, Valle MC, Sarango SC, Izquierdo IA, Ojea JIM, Azcarate RV.   +8 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Impacts of Cognitive Load and Task Initiation Timing on Gait Performance in Parkinson's Disease: A Dual-Task Paradigm Study. [PDF]

CNS Neurosci Ther
Okusa S, Kimura T, Tanamachi K, Kaneko F, Yamada Y, Kawakami M, Nakahara J, Seki M.   +7 more
europepmc   +1 more source

Dual-frequency microstrip antennas

, 2012
[[abstract]]This paper presents the design of a dual-port microstrip patch antenna with dual-frequency operation. Two different feed mechanisms—aperture coupling and inset coplanar microstrip line—are used to excite the TM10 and TM01 modes, respectively,
Chuo, Feng-Pin; Chen, Tsair-Rong; Row, Jeen-Sheen
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Cigarette, e-cigarette and dual use among Malaysian adolescents: A secondary analysis of the 2017 and 2022 adolescent health surveys. [PDF]

Tob Induc Dis
Lim KK, Mahjom M, Awaluddin SM, Shawaluddin NS, Chan YY, Abd Hamid HA, Lim HL, Cheong KC, Lim KH.   +8 more
europepmc   +1 more source