Results 191 to 200 of about 1,805,046 (316)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Combining shallow and deep neural networks on pseudo-color enhanced images for digital breast tomosynthesis lesion classification. [PDF]

Front Digit Health
Yang Z, Liu Y, Smedby Ö, Moreno R.
europepmc   +1 more source

The dual role of mitochondrial superoxide in arsenite toxicity: Signaling at the boundary between apoptotic commitment and cytoprotection

, 2018
Mara Fiorani, Andrea Guidarelli, Valentina Capellacci, Liana Cerioni, Rita Crinelli, Orazio Cantoni   +5 more
openalex   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mechanism of ultrasonic treatment affecting the conformation and properties of oat-whey dual-protein gel. [PDF]

Ultrason Sonochem
Liu L, Li S, Wang S, Che J, Qin P, Wang Z, Huang Y, Shi Y, Li Y, Wang Q.   +9 more
europepmc   +1 more source

Dual-function terahertz metamaterial absorber based on microfluidic structures

Hongyi Ge, Keke Jia, Yuying Jiang, Yuwei Bu, Yujie Zhang, Yuan Zhang, Qingcheng Sun   +6 more
openalex   +1 more source

A note on Köthe‐Toeplitz duals of certain sequence spaces and their matrix transformations

, 1993
B. Choudhary, Shailendra Kumar Mishra
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Prevalence of dual-donating amines in key regions of functional RNAs. [PDF]

RNA
Veenis AJ, Saon MS, Bevilacqua PC.
europepmc   +1 more source

Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy

Rubén Rodríguez, Anne C. Hergarden, Shyam Krishnan, Marikris Morales, D. K. C. Lam, Ted Tracy, Teresa Tang, A. R. Patton, Craig R. Lee, Asmita Pant, Daniel A. Erlanson, Johan Enquist, Derek B.J. Bone, Ray Fucini, Damian Bialonczyk, Stig K. Hansen, Jian Luo, Manu V. Chakravarthy   +17 more
openalex   +2 more sources