Results 211 to 220 of about 1,805,046 (316)

Parallel vs. Orthogonal dual plating for distal humerus fractures: a systematic review and pooled analysis of functional outcomes and union times. [PDF]

J Orthop Surg Res
John RLS, Brancaccio H, Spicer S, Shah KP, Alexander T, Haydel C, Pulido S, McMillan S.   +7 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

An enhanced dual inception-attention-BiGRU-attention model integrating wavelet transform for wearable sensor-based human activity recognition. [PDF]

Sci Rep
Zhang X, Wang Y, Deng T.
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Effects of Dual-Electrode Asynchrony on Temporal Pitch Discrimination With Amplitude Modulation and Short Inter-Pulse Intervals in Cochlear Implant Listeners. [PDF]

Trends Hear
Lindenbeck MJ, Majdak P, Laback B.
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Adolescent cyberbullying and polysubstance use: unpacking sex differences. [PDF]

Sci Rep
Richardson MK, Agbonlahor O, Hart JL, Diaby M, Mattingly DT.   +4 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Dual-key slot mmwave antenna array with dual-band performance at 28 GHz and 38 GHz using characteristic mode analysis. [PDF]

Sci Rep
Kiani SH, Ibrahim MI, Shariff BGP, Khan MA, Mugheri AA, Ali T, Rafique U, Mostafa H, Dalarsson M.   +8 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source